Johnson Tanner M, Byrd Thomas F, Drummond Wendi K, Childs-Kean Lindsey M, Mahoney Monica V, Pearson Jeffrey C, Rivera Christina G
Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
Division of Infectious Diseases, University of New Mexico, Albuquerque, NM, USA.
Infect Dis Ther. 2023 Feb;12(2):343-365. doi: 10.1007/s40121-022-00750-5. Epub 2023 Jan 7.
Nontuberculous mycobacteria (NTM) are a group of atypical bacteria that may cause a spectrum of clinical manifestations, including pulmonary, musculoskeletal, skin and soft tissue, and cardiac infections. Antimycobacterial medication regimens for NTM infections require multiple agents with prolonged treatment courses and are often associated with poor tolerance in patients and suboptimal clinical outcomes. This review summarizes NTM pharmacotherapy, including treatment concepts, preferred medication regimens according to NTM species and site of infection, and emerging treatment methods for difficult-to-treat species.
非结核分枝杆菌(NTM)是一组非典型细菌,可引起一系列临床表现,包括肺部、肌肉骨骼、皮肤和软组织以及心脏感染。NTM感染的抗分枝杆菌药物治疗方案需要多种药物且疗程延长,并且常与患者耐受性差和临床效果欠佳相关。本综述总结了NTM的药物治疗,包括治疗理念、根据NTM菌种和感染部位的首选药物治疗方案以及针对难治菌种的新兴治疗方法。