Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre "Kurchatov Institute", 188300 Gatchina, Russia.
Cells. 2022 Dec 31;12(1):170. doi: 10.3390/cells12010170.
Huntington's disease (HD) is one of the human neurodegenerative diseases for which there is no effective treatment. Therefore, there is a strong demand for a novel neuroprotective agent that can alleviate its course. Fullerene derivatives are considered to be such agents; however, they need to be comprehensively investigated in model organisms. In this work, neuroprotective activity of C(OH) and CO(OH) fullerenols was analyzed for the first time in a transgenic model of HD. Lifespan, behavior, oxidative stress level and age-related neurodegeneration were assessed in flies with the pathogenic Huntingtin protein expression in nerve cells. Feed supplementation with hydroxylated C fullerene and CO dimer oxide molecules was shown to diminish the oxidative stress level and neurodegenerative processes in the flies' brains. Thus, fullerenes displayed neuroprotective activity in this model.
亨廷顿病（HD）是一种人类神经退行性疾病，目前尚无有效的治疗方法。因此，人们强烈需要一种新型的神经保护剂来缓解其病程。富勒烯衍生物被认为是此类药物；然而，它们需要在模式生物中进行全面研究。在这项工作中，首次在 HD 的转基因模型中分析了 C（OH）和 CO（OH）富勒醇的神经保护活性。在具有神经细胞中致病性亨廷顿蛋白表达的果蝇中，评估了寿命、行为、氧化应激水平和与年龄相关的神经退行性变。用羟基化 C 富勒烯和 CO 二聚体氧化物分子进行饲料补充，可降低果蝇大脑中的氧化应激水平和神经退行性过程。因此，富勒烯在该模型中表现出神经保护活性。
