Hu Xiaoyu, Xue Zhuang, He Kewen, Tian Yaru, Chen Yu, Zhao Mengyu, Yu Jinming, Yue Jinbo
Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430064, China.
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Science, Jinan 250117, China.
Cancers (Basel). 2022 Dec 29;15(1):219. doi: 10.3390/cancers15010219.
Neoadjuvant long-course concurrent chemoradiation plus surgery, followed by optional adjuvant chemotherapy, is a standard of care for locally advanced rectal cancer (LARC). However, this traditional approach has several limitations, including low pathological complete response (pCR) (10-25%), high metastasis rate (30-35%), and highly inconsistent compliance with adjuvant chemotherapy (25-75%). Treatment modalities for LARC have dramatically evolved in recent years. Multiple clinical trials have focused on optimizing strategies to achieve a win-win situation for oncologic outcomes and functions. Here, we review the latest studies into optimizing neoadjuvant treatment for LARC.
新辅助长程同步放化疗加手术,随后根据情况进行辅助化疗,是局部晚期直肠癌(LARC)的标准治疗方案。然而,这种传统方法存在一些局限性,包括病理完全缓解率(pCR)低(10%-25%)、转移率高(30%-35%)以及辅助化疗的依从性极不一致(25%-75%)。近年来,LARC的治疗模式发生了巨大变化。多项临床试验致力于优化策略,以实现肿瘤治疗效果和功能的双赢。在此,我们综述了关于优化LARC新辅助治疗的最新研究。