Nishizawa Toshihiro, Ueda Takashi, Ebinuma Hirotoshi, Toyoshima Osamu, Suzuki Hidekazu
Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital, Narita 286-8520, Japan.
Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Cancers (Basel). 2022 Dec 30;15(1):239. doi: 10.3390/cancers15010239.
In this review, we summarize up-to-date reports with five-year observation after colorectal endoscopic submucosal dissection (ESD). Five-year cause-specific survival rates ranged from 98.6 to 100%. The local recurrence rates ranged from 1.1 to 2.2% in complete resection and 7.5 to 25.0% in incomplete resection. Incomplete resection was a risk factor for local recurrence. In non-curative ESD, five-year cause-specific survival rates ranged from 93.8 to 100% with additional surgery, and 92.7 to 99.1% without surgery. The choice of additional surgery should be based on the individual patient's age, concomitant diseases, wishes, life expectancy, and the risk of lymph node metastasis. The metachronous cancer rates ranged from 0.22 to 1.1%. Both local recurrence and metachronous tumors should be checked with a follow-up colonoscopy after ESD.
在本综述中，我们总结了结直肠内镜黏膜下剥离术（ESD）后五年观察的最新报告。五年病因特异性生存率在98.6%至100%之间。完全切除后的局部复发率在1.1%至2.2%之间，不完全切除后的局部复发率在7.5%至25.0%之间。不完全切除是局部复发的危险因素。在非根治性ESD中，接受额外手术的患者五年病因特异性生存率在93.8%至100%之间，未接受手术的患者在92.7%至99.1%之间。额外手术的选择应基于个体患者的年龄、伴随疾病、意愿、预期寿命以及淋巴结转移风险。异时性癌发生率在0.22%至1.1%之间。ESD后应通过结肠镜随访检查局部复发和异时性肿瘤。
