Hossain Md Sanower, Karuniawati Hidayah, Jairoun Ammar Abdulrahman, Urbi Zannat, Ooi Der Jiun, John Akbar, Lim Ya Chee, Kibria K M Kaderi, Mohiuddin A K M, Ming Long Chiau, Goh Khang Wen, Hadi Muhammad Abdul
Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia.
Faculty of Science, Sristy College of Tangail, Tangail 1900, Bangladesh.
Cancers (Basel). 2022 Mar 29;14(7):1732. doi: 10.3390/cancers14071732.
Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fatalities related to CRC are growing in developing countries too. CRC detected early is entirely curable by surgery and subsequent medications. However, the recurrence rate is high, and cancer drug resistance increases the treatment failure rate. Access to early diagnosis and treatment of CRC for survival is somewhat possible in developed countries. However, these facilities are rarely available in developing countries. Highlighting the current status of CRC, its development, risk factors, and management is crucial in creating public awareness. Therefore, in this review, we have comprehensively discussed the current global epidemiology, drug resistance, challenges, risk factors, and preventive and treatment strategies of CRC. Additionally, there is a brief discussion on the CRC development pathways and recommendations for preventing and treating CRC.
结直肠癌（CRC）是第二大致命性癌症。在未来几十年，全球发病率和死亡率可能会上升。尽管在高收入国家，与结直肠癌相关的死亡人数非常高，但在发展中国家，结直肠癌的发病率和死亡率也在上升。早期发现的结直肠癌通过手术及后续药物治疗完全可以治愈。然而，复发率很高，并且癌症耐药性增加了治疗失败率。在发达国家，获得早期诊断和治疗以提高结直肠癌患者生存率在一定程度上是可行的。然而，这些设施在发展中国家很少见。强调结直肠癌的现状、发展、风险因素和管理对于提高公众意识至关重要。因此，在本综述中，我们全面讨论了结直肠癌当前的全球流行病学、耐药性、挑战、风险因素以及预防和治疗策略。此外，还简要讨论了结直肠癌的发展途径以及预防和治疗结直肠癌的建议。
