Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
Department of Physiology and Biochemistry, Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland.
Int J Mol Sci. 2022 Dec 22;24(1):205. doi: 10.3390/ijms24010205.
In this paper, we present a literature review of the role of CXC motif chemokine ligand 1 (CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular system, respiratory system and skin. CXCL1, a cytokine belonging to the CXC sub-family of chemokines with CXC motif chemokine receptor 2 (CXCR2) as its main receptor, causes the migration and infiltration of neutrophils to the sites of high expression. This implicates CXCL1 in many adverse conditions associated with inflammation and the accumulation of neutrophils. The aim of this study was to describe the significance of CXCL1 in selected diseases of the cardiovascular system (atherosclerosis, atrial fibrillation, chronic ischemic heart disease, hypertension, sepsis including sepsis-associated encephalopathy and sepsis-associated acute kidney injury), the respiratory system (asthma, chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis, coronavirus disease 2019 (COVID-19), influenza, lung transplantation and ischemic-reperfusion injury and tuberculosis) and the skin (wound healing, psoriasis, sunburn and ). Additionally, the significance of CXCL1 is described in vascular physiology, such as the effects of CXCL1 on angiogenesis and arteriogenesis.
本文对趋化因子配体 1（CXCL1）在生理学以及心血管系统、呼吸系统和皮肤的某些重大非癌症疾病中的作用进行了文献回顾。CXCL1 是一种细胞因子，属于趋化因子 CXC 亚家族，其主要受体为 CXC 趋化因子受体 2（CXCR2），它促使中性粒细胞向高表达部位迁移和浸润。这意味着 CXCL1 与许多与炎症和中性粒细胞积聚有关的不良情况有关。本研究的目的是描述 CXCL1 在某些心血管系统疾病（动脉粥样硬化、心房颤动、慢性缺血性心脏病、高血压、败血症包括败血症相关性脑病和败血症相关性急性肾损伤）、呼吸系统疾病（哮喘、慢性阻塞性肺疾病（COPD）、慢性鼻-鼻窦炎、2019 年冠状病毒病（COVID-19）、流感、肺移植和缺血再灌注损伤以及结核病）和皮肤疾病（伤口愈合、银屑病、晒伤和）中的意义。此外，还描述了 CXCL1 在血管生理学中的意义，如 CXCL1 对血管生成和动脉生成的影响。
