Marchetta Stella, Verbelen Tom, Claessen Guido, Quarck Rozenn, Delcroix Marion, Godinas Laurent
Department of Cardiology, CHC Mont-Légia, 4000 Liège, Belgium.
Department of Cardiac Surgery, University Hospitals Leuven, 3000 Leuven, Belgium.
J Clin Med. 2022 Dec 21;12(1):47. doi: 10.3390/jcm12010047.
While chronic thromboembolic pulmonary hypertension (CTEPH) results from macroscopic and microscopic obstruction of the pulmonary vascular bed, the function of the right ventricle (RV) and increased RV afterload are the main determinants of its symptoms and prognosis. In this review, we assess RV function in patients diagnosed with CTEPH with a focus on the contributions of RV afterload and dysfunction to the pathogenesis of this disease. We will also discuss changes in RV function and geometry in response to treatment, including medical therapy, pulmonary endarterectomy, and balloon pulmonary angioplasty.
虽然慢性血栓栓塞性肺动脉高压（CTEPH）是由肺血管床的宏观和微观阻塞引起的，但右心室（RV）的功能以及RV后负荷增加是其症状和预后的主要决定因素。在这篇综述中，我们评估了被诊断为CTEPH的患者的RV功能，重点关注RV后负荷和功能障碍对该疾病发病机制的影响。我们还将讨论RV功能和几何形状在治疗（包括药物治疗、肺动脉内膜剥脱术和球囊肺动脉成形术）后的变化。
