Tardáguila-García Aroa, Álvaro-Afonso Francisco Javier, García-Madrid Marta, López-Moral Mateo, Sanz-Corbalán Irene, Lázaro-Martínez José Luis
Diabetic Foot Unit, Clínica Universitaria de Podología, Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
J Clin Med. 2023 Jan 1;12(1):345. doi: 10.3390/jcm12010345.
To compare the healing time in patients with diabetic foot osteomyelitis according to the presence or absence of clinical signs of infection, variation of blood parameters, the presence of different radiological signs, and the treatment received for the management of osteomyelitis.
A prospective observational study was carried out in a specialised Diabetic Foot Unit between November 2014 and November 2018. A total of 116 patients with osteomyelitis were included in the study (treated by either a surgical or medical approach). During the baseline visit, we assessed the diagnosis of osteomyelitis, demographic characteristics and medical history, vascular and neurological examination, clinical signs of infection, increased blood parameters, radiological signs of osteomyelitis, and the treatment to manage osteomyelitis. We analysed the association between the presence of clinical signs of infection, variation of blood parameters, presence of radiological signs, and treatment received for management of osteomyelitis with the healing time.
The mean time to ulcer healing was 15.8 ± 9.7 weeks. Concerning healing times, we did not find an association with the presence of clinical signs of infection or with the increase in blood parameters, except in the case of eosinophils, which with higher values appear to increase the healing time (U = 66, z = -2.880, = 0.004). Likewise, no relationship has been found between healing time and the appearance of the different radiological signs of osteomyelitis, nor depending on the treatment administered for the management of osteomyelitis.
High levels of eosinophils are associated with a longer healing time of diabetic foot ulcers complicated with osteomyelitis, finding no other factors related to increased healing time.
根据感染的临床体征、血液参数变化、不同影像学表现以及针对骨髓炎的治疗方法，比较糖尿病足骨髓炎患者的愈合时间。
2014年11月至2018年11月在一家专业糖尿病足治疗中心进行了一项前瞻性观察研究。共有116例骨髓炎患者纳入研究（采用手术或药物治疗）。在基线访视时，我们评估了骨髓炎的诊断、人口统计学特征和病史、血管和神经检查、感染的临床体征、血液参数升高、骨髓炎的影像学表现以及骨髓炎的治疗方法。我们分析了感染的临床体征、血液参数变化、影像学表现以及骨髓炎治疗与愈合时间之间的关联。
溃疡愈合的平均时间为15.8±9.7周。关于愈合时间，除嗜酸性粒细胞外，我们未发现其与感染的临床体征或血液参数升高有关，嗜酸性粒细胞值较高时似乎会延长愈合时间（U = 66，z = -2.880，P = 0.004）。同样，未发现愈合时间与骨髓炎不同影像学表现之间的关系，也未发现其与骨髓炎治疗方法有关。
高水平的嗜酸性粒细胞与糖尿病足溃疡合并骨髓炎的愈合时间延长有关，未发现其他与愈合时间延长相关的因素。
