手性联萘酚衍生物的不对称合成进展。
Advances in the Asymmetric Synthesis of BINOL Derivatives.
机构信息
Centre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, Brazil.
出版信息
Molecules. 2022 Dec 20;28(1):12. doi: 10.3390/molecules28010012.
BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed.
BINOL 衍生物具有重要的生物活性，是重要的手性配体和催化剂。由于这些特性，它们的不对称合成引起了科学界的兴趣。在这项工作中，我们综述了获得手性 BINOL 的最有效方法，重点介绍了金属配合物和有机催化剂以及动力学拆分的应用。还讨论了 BINOL 的进一步衍生化。
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