对映选择性铁/双喹啉二胺配体催化的 2-萘酚氧化偶联反应。
Enantioselective Iron/Bisquinolyldiamine Ligand-Catalyzed Oxidative Coupling Reaction of 2-Naphthols.
机构信息
Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
出版信息
Molecules. 2020 Feb 14;25(4):852. doi: 10.3390/molecules25040852.
An iron-catalyzed asymmetric oxidative homo-coupling of 2-naphthols for the synthesis of 1,1'-Bi-2-naphthol (BINOL) derivatives is reported. The coupling reaction provides enantioenriched BINOLs in good yields (up to 99%) and moderate enantioselectivities (up to 81:19 er) using an iron-complex generated in situ from Fe(ClO) and a bisquinolyldiamine ligand [(1,2)-,-di(quinolin-8-yl)cyclohexane-1,2-diamine, ]. A number of ligands (-) and the analogs of , with various substituents and chiral backbones, were synthesized and examined in the oxidative coupling reactions.
报道了一种铁催化的 2-萘酚不对称氧化偶联反应，用于合成 1,1'-联萘-2,2'-二醇（BINOL）衍生物。该偶联反应使用原位生成的铁配合物[Fe(ClO)]和双喹啉二胺配体[(1,2)-,-二（喹啉-8-基）环己烷-1,2-二胺]，以良好的收率（高达 99%）和中等的对映选择性（高达 81:19 er）得到了手性富集的 BINOL。合成了一系列配体（-）和类似物 ，具有各种取代基和手性骨架，并在氧化偶联反应中进行了测试。
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