纳乌克莱酰胺A - E，来自阔叶乌檀的新型单萜吲哚生物碱。

Naucleamides A-E, new monoterpene indole alkaloids from Nauclea latifolia.

作者信息

Shigemori Hideyuki, Kagata Toshinori, Ishiyama Haruaki, Morah Frank, Ohsaki Ayumi, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2003 Jan;51(1):58-61. doi: 10.1248/cpb.51.58.

DOI:10.1248/cpb.51.58

PMID:12520129

Abstract

Five new monoterpene indole alkaloids, naucleamides A-E (1-5), were isolated from the bark and wood of Nauclea latifolia, and the structures and relative stereochemistry were elucidated from the spectroscopic data. Naucleamide E (5) is a unique monoterpene indole alkaloid possessing a pentacyclic ring system with an amino acetal bridge.

摘要

从阔叶乌檀的树皮和木材中分离出了5种新的单萜吲哚生物碱，即乌檀酰胺A - E（1 - 5），并根据光谱数据阐明了其结构和相对立体化学。乌檀酰胺E（5）是一种独特的单萜吲哚生物碱，具有带有氨基缩醛桥的五环系统。