Wageningen Food and Biobased Research, Wageningen University & Research, 6708 WG Wageningen, The Netherlands.
Department of Cardiology, Ziekenhuis Gelderse Vallei, 6710 HN Ede, The Netherlands.
Nutrients. 2022 Dec 22;15(1):49. doi: 10.3390/nu15010049.
Kori-tofu is a frozen soy tofu, and soy consumption is associated with positive effects on cardiometabolic health markers. We aimed to assess the potential of Kori-tofu to improve cardiometabolic health outcomes in humans by repetitive daily consumption. In a double-blind randomized controlled cross-over trial, 45 subjects aged 40-70 years with (mildly) elevated cholesterol levels, received a four week Kori-tofu intervention or whey protein control intervention with a four week wash-out period in between. Cardiometabolic biomarkers were measured before and after both interventions. A significant decrease in total, low-density lipids (LDL), and high-density lipids (HDL) cholesterol, Hemoglobin A1c (HbA1c), fructosamine and systolic blood pressure was observed within the Kori-tofu intervention. However, many of these findings were also observed in the control intervention. Only adiponectin changes were different between treatments but did not change significantly within interventions. Improvements in cardiometabolic markers within the Kori-tofu intervention point toward potential beneficial health effects. Due to the lack of significant effects as compared to control, there is, however, currently no substantiating evidence to claim that Kori-tofu has beneficial effects on cardiometabolic health.
科里豆腐是一种冷冻豆腐，大豆的摄入与改善心血管代谢健康标志物有关。我们旨在通过重复日常摄入来评估科里豆腐对改善人体心血管代谢健康结果的潜力。在一项双盲随机对照交叉试验中，45 名年龄在 40-70 岁、胆固醇水平（轻度）升高的受试者接受了为期四周的科里豆腐干预或乳清蛋白对照干预，中间有四周的洗脱期。在两次干预前后均测量了心血管代谢生物标志物。在科里豆腐干预期间，总胆固醇、低密度脂蛋白 (LDL)、高密度脂蛋白 (HDL) 胆固醇、糖化血红蛋白 (HbA1c)、果糖胺和收缩压均显著下降。然而，在对照干预中也观察到了许多这些发现。只有脂联素的变化在两种治疗方法之间有所不同，但在干预过程中并没有显著变化。科里豆腐干预期间心血管代谢标志物的改善表明其可能对健康有益。然而，由于与对照相比，效果不显著，目前没有确凿的证据表明科里豆腐对心血管代谢健康有有益的影响。
