Nilsson Sofie, Tokariev Anton, Metsäranta Marjo, Norman Elisabeth, Vanhatalo Sampsa
Pediatrics, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, 22185 Lund, Sweden.
BABA Center, Departments of Pediatrics and Clinical Neurophysiology, Children's Hospital, Helsinki University Hospital Helsinki, 00029 Helsinki, Finland.
Sensors (Basel). 2022 Dec 31;23(1):444. doi: 10.3390/s23010444.
Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable.
EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27-42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively.
The visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612, = 0.006) and parietal (rho = -0.489, = 0.035) derivations. The change in ASI was negatively correlated to baseline values in the interhemispheric (rho = -0.753; = 0.001) and frontal comparisons (rho = -0.496; = 0.038).
Cerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis.
在新生儿重症监护期间，为了开发安全有效的治疗方法，需要有关镇痛和镇静药物对大脑影响的数据。脑电图（EEG）是一种客观但依赖于解释者的监测皮层活动的方法。定量计算机分析可能会揭示其他方法无法检测到的脑电图变化。
回顾性收集了21例在新生儿护理期间接受右美托咪定治疗的婴儿（平均孕周38.7周；范围27 - 42周）的脑电图记录。将这些记录转换为计算特征，并进行视觉分析，同时使用两种计算方法分别量化功率（范围脑电图；rEEG）的相对和绝对变化以及皮质 - 皮质同步性（激活同步指数；ASI）。
视觉评估未发现任何药物作用。在rEEG分析中，发现基线与参考额叶（rho = 0.612，P = 0.006）和顶叶（rho = -0.489，P = 0.035）导联之间呈负相关。ASI的变化在半球间（rho = -0.753；P = 0.001）和额叶比较（rho = -0.496；P = 0.038）中与基线值呈负相关。
脑电图确定的右美托咪定对新生儿大脑的影响与给药前的皮层活动有关，这表明基线时较高的脑活动水平（较高的rEEG）与右美托咪定更明显的降低作用相关。计算测量表明药物对整体皮层活动和皮质 - 皮质通信均有影响。这些影响在视觉分析中并不明显。
