Divisão Neonatal, Grupo Santa Joana, São Paulo, SP, Brazil; Divisão Neonatal, Departamento de Pediatria, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil; Organização Protegendo Cérebros e Salvando Futuros, São Paulo, SP, Brazil; Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil.
Organização Protegendo Cérebros e Salvando Futuros, São Paulo, SP, Brazil; Escola Paulista de Enfermagem, Departamento de Enfermagem Pediátrica, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
J Pediatr (Rio J). 2022 Nov-Dec;98(6):565-571. doi: 10.1016/j.jped.2021.10.008. Epub 2022 Jan 2.
Amplitude-integrated electroencephalography (aEEG) is a simplified bedside neurophysiology tool that has been implemented in the neonatal intensive care unit and studied in an extensive range of clinical applications in the past decade. This critical review aimed to evaluate a variety of clinical applications of aEEG monitoring in diagnosis, clinical management, and prognosis assessment in critically ill neonates.
The databases of Pubmed, SciELO, Lilacs, and Cochrane, books, and other online resources were consulted, as well as sources of professional experiences.
The clinical use of aEEG to access real-time brain function, background activity, and utility in seizures detection has been described. A critical review was realized considering the authors' professional experience. Newborns with hypoxic-ischemic encephalopathy and seizures screening represent the most common studied population. However, several studies have shown interesting applications on preterm infants, newborns with congenital heart disease, and other clinical situations of high risk of injury to the developing brain.
The aEEG has shown to be a useful non-invasive bedside monitor that aids in evaluating brain function, background activity, and cyclicity. aEEG findings have also demonstrated good prognostic value in a group of critically ill neonates. The aEEG seizure diagnosis capability has limitations, which have been already well established. The use of neonatal brain monitoring such as aEEG was shown to give valuable information in several high-risk clinical situations.
振幅整合脑电图（aEEG）是一种简化的床边神经生理学工具，已在新生儿重症监护病房中实施，并在过去十年中在广泛的临床应用中进行了研究。本综述旨在评估 aEEG 监测在危重新生儿的诊断、临床管理和预后评估中的各种临床应用。
检索了 Pubmed、SciELO、Lilacs 和 Cochrane 数据库、书籍和其他在线资源以及专业经验来源。
描述了 aEEG 用于实时评估脑功能、背景活动和检测癫痫发作的用途。结合作者的专业经验进行了批判性评价。缺氧缺血性脑病和癫痫发作筛查的新生儿是最常见的研究人群。然而，一些研究表明，aEEG 在早产儿、先天性心脏病新生儿和其他脑发育损伤风险高的临床情况下具有有趣的应用。
aEEG 已被证明是一种有用的非侵入性床边监测器，可用于评估脑功能、背景活动和周期性。aEEG 结果在一组危重新生儿中也显示出良好的预后价值。aEEG 癫痫诊断能力存在局限性，这已经得到了很好的证实。在一些高危临床情况下，使用新生儿脑监测（如 aEEG）可提供有价值的信息。
