从雷公藤叶中分离得到的二萜和木脂素。
Diterpenoids and lignans from the leaves of Tripterygium wilfordii.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
Fitoterapia. 2018 Sep;129:133-137. doi: 10.1016/j.fitote.2018.06.026. Epub 2018 Jun 27.
Three new diterpenoids (1-3) and three new esterifying lignans (4-6) were isolated from the leaves of Tripterygium wilfordii. The structures of these compounds were elucidated on the basis of spectroscopic techniques (UV, IR, NMR, HRESIMS, and ECD method). At 10 μmol/L, compounds 4-6 showed moderate inhibitory effects on nitric oxide production in LPS-induced macrophages with inhibitory rate >80%.
从雷公藤的叶子中分离得到三个新的二萜（1-3）和三个新的酯化木脂素（4-6）。这些化合物的结构是基于光谱技术（UV、IR、NMR、HRESIMS 和 ECD 方法）阐明的。在 10 μmol/L 时，化合物 4-6 对 LPS 诱导的巨噬细胞中一氧化氮的产生具有中等抑制作用，抑制率>80%。
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