急性应激反应时，催产素对下丘脑室旁核促肾上腺皮质激素释放激素（CRH）神经元的下丘脑内效应。
Intrahypothalamic effects of oxytocin on PVN CRH neurons in response to acute stress.
作者信息
Pati Dipa, Krause Eric G, Frazier Charles J
机构信息
Department of Pharmacodynamics, College of Pharmacy, University of Florida.
Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL.
出版信息
Curr Opin Endocr Metab Res. 2022 Oct;26. doi: 10.1016/j.coemr.2022.100382. Epub 2022 Jul 19.
Abstract
Much of the centrally available oxytocin (OT) is synthesized in magnocellular neurons located in the paraventricular nucleus of the hypothalamus. This same area is home to parvocellular corticotropin-releasing hormone (CRH) synthesizing neurons that regulate activation of the hypothalamic-pituitary-adrenal (HPA) axis. A large body of data indicates that complex interactions between these systems inextricably link central OT signaling with the neuroendocrine response to stress. This review focuses on a small but diverse set of cellular and synaptic mechanisms that have been proposed to underlie intrahypothalamic OT/CRF interactions during the response to acute stress.
摘要
大部分中枢可用的催产素（OT）是在下丘脑室旁核中的大细胞神经元中合成的。这个区域也是合成促肾上腺皮质激素释放激素（CRH）的小细胞神经元的所在地，这些神经元调节下丘脑-垂体-肾上腺（HPA）轴的激活。大量数据表明，这些系统之间的复杂相互作用将中枢OT信号与对应激的神经内分泌反应紧密联系在一起。本综述聚焦于一小部分但多样的细胞和突触机制，这些机制被认为是急性应激反应期间下丘脑内OT/CRF相互作用的基础。
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