Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Tochigi 329-0498, Japan.
Int J Mol Sci. 2021 Dec 23;23(1):150. doi: 10.3390/ijms23010150.
Oxytocin has been revealed to work for anxiety suppression and anti-stress as well as for psychosocial behavior and reproductive functions. Oxytocin neurons are activated by various stressful stimuli. The oxytocin receptor is widely distributed within the brain, and oxytocin that is released or diffused affects behavioral and neuroendocrine stress responses. On the other hand, there has been an increasing number of reports on the role of oxytocin in allostasis and resilience. It has been shown that oxytocin maintains homeostasis, shifts the set point for adaptation to a changing environment (allostasis) and contributes to recovery from the shifted set point by inducing active coping responses to stressful stimuli (resilience). Recent studies have suggested that oxytocin is also involved in stress-related disorders, and it has been shown in clinical trials that oxytocin provides therapeutic benefits for patients diagnosed with stress-related disorders. This review includes the latest information on the role of oxytocin in stress responses and adaptation.
催产素已被证明具有抑制焦虑、抗压、调节社会心理行为和生殖功能的作用。各种应激刺激会激活催产素神经元。催产素受体在大脑中广泛分布，释放或扩散的催产素会影响行为和神经内分泌应激反应。另一方面，越来越多的报告表明催产素在体内平衡和适应力方面发挥作用。研究表明，催产素维持体内平衡，将适应变化环境的设定点（体内平衡）转移，并通过对应激刺激产生积极的应对反应来促进从转移的设定点恢复（适应力）。最近的研究表明，催产素也与应激相关障碍有关，临床试验表明，催产素为应激相关障碍患者提供了治疗益处。本文综述了催产素在应激反应和适应中的作用的最新信息。
