Faran M E, Turell M J, Romoser W S, Routier R G, Gibbs P H, Cannon T L, Bailey C L
U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701.
Am J Trop Med Hyg. 1987 Sep;37(2):403-9. doi: 10.4269/ajtmh.1987.37.403.
The effect of Rift Valley fever (RVF) viral infection on the survival of female Culex pipiens was examined. In 3 experiments in which mosquitoes ingested RVF virus, there was a 44% decrease in survival to days 14-16 for transmitting vs. nontransmitting mosquitoes, and a 48% decrease in survival for individuals with disseminated vs. nondisseminated infections. These results were corroborated by other experiments in which survival of mosquitoes intrathoracically inoculated with RVF virus was compared with that of those inoculated with diluent. In both the per os and inoculation tests, uninfected mosquitoes survived significantly longer than infected mosquitoes. Even though mosquitoes with disseminated infections had a lower survival rate than did uninfected mosquitoes, dissemination and transmission rates were similar at days 7 and 14-18 after the infectious bloodmeal. This suggests that nondisseminated individuals were developing disseminated infections and becoming capable of transmitting virus between days 7 and 14-18 at approximately the same rate older transmitters were dying. The decreased survival associated with RVF viral infection should be considered in predictive models of this disease.
研究了裂谷热（RVF）病毒感染对雌性致倦库蚊存活的影响。在3项实验中，让蚊子摄入RVF病毒，与未传播病毒的蚊子相比，传播病毒的蚊子在第14至16天的存活率下降了44%，有播散性感染的个体与无播散性感染的个体相比，存活率下降了48%。其他实验将经胸腔接种RVF病毒的蚊子的存活率与接种稀释剂的蚊子的存活率进行了比较，证实了这些结果。在经口和接种试验中，未感染的蚊子存活时间均显著长于感染的蚊子。尽管有播散性感染的蚊子的存活率低于未感染的蚊子，但在感染性血餐后第7天和第14至18天，播散率和传播率相似。这表明，在第7天至第14至18天之间，未播散病毒的个体正在发展为播散性感染并开始能够传播病毒，其速度与较老的传播者死亡的速度大致相同。在该疾病的预测模型中应考虑与RVF病毒感染相关的存活率下降。
