美国女性的糖尿病表型是否因种族/族裔而异？一项基于人群的聚类分析。
Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis.
作者信息
Choi Daesung, Jones-Antwi Rebecca, Ali Mohammed K, Patel Shivani A
机构信息
Rollins School of Public Health, Emory University, Atlanta, GA, USA.
出版信息
Metabol Open. 2022 Dec 22;17:100225. doi: 10.1016/j.metop.2022.100225. eCollection 2023 Mar.
OBJECTIVE
US women exhibit racial disparities in the lifetime risk of diabetes and related outcomes. Identifying heterogeneity in clinical presentation may assist with reducing racial disparities in diabetes outcomes. We identified clinical phenotypes of diabetes and examined their racial and ethnic distribution in US women.
RESEARCH DESIGN AND METHODS
We conducted cluster analysis based on five factors in US women with diagnosed diabetes assessed in the National Health and Nutrition Examination Surveys 1999-2018 (n = 825). Multinomial logistic regression analysis was performed to identify racial and ethnic differences in the distribution of phenotypes.
RESULTS
We identified four distinct clinical phenotypes. Two phenotypes, mild age-related and severe insulin-deficient diabetes, each included approximately a third of women. Mild insulin-resistant and severe insulin-resistant diabetes phenotypes accounted for 19.9% and 13.7%, respectively. The distribution of clusters did not differ by race and ethnicity.
CONCLUSIONS
The prevalence of four clinically distinct diabetes phenotypes identified in US women did not differ by race and ethnicity.
目的
美国女性在糖尿病终生风险及相关结局方面存在种族差异。识别临床表现的异质性可能有助于减少糖尿病结局方面的种族差异。我们确定了糖尿病的临床表型，并研究了其在美国女性中的种族和民族分布。
研究设计与方法
我们基于1999 - 2018年美国国家健康与营养检查调查中确诊为糖尿病的女性的五个因素进行了聚类分析（n = 825）。进行多项逻辑回归分析以确定表型分布中的种族和民族差异。
结果
我们确定了四种不同的临床表型。两种表型，轻度年龄相关性糖尿病和重度胰岛素缺乏性糖尿病，每种表型约占女性的三分之一。轻度胰岛素抵抗性糖尿病和重度胰岛素抵抗性糖尿病表型分别占19.9%和13.7%。聚类分布在种族和民族方面没有差异。
结论
在美国女性中确定的四种临床不同的糖尿病表型的患病率在种族和民族方面没有差异。
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