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α-生育酚琥珀酸酯胶束递送的阿霉素月桂酰腙衍生物对胶质母细胞瘤治疗的协同作用

Synergistic effect of doxorubicin lauroyl hydrazone derivative delivered by α-tocopherol succinate micelles for the treatment of glioblastoma.

作者信息

Wang Mingchao, Malfanti Alessio, Bastiancich Chiara, Préat Véronique

机构信息

Université Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Brussels, Belgium.

Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.

出版信息

Int J Pharm X. 2022 Dec 21;5:100147. doi: 10.1016/j.ijpx.2022.100147. eCollection 2023 Dec.

DOI:10.1016/j.ijpx.2022.100147
PMID:36620521
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9813532/
Abstract

We hypothesized that tocopherol succinate (TOS) and D-α-tocopherol polyethylene2000 succinate (TPGS) micelles could work as a drug delivery system while enhancing the anti-cancer efficacy of doxorubicin lauryl hydrazone derivative (DOXC) for the treatment of glioblastoma. The DOXC-TOS-TPGS micelles were formulated with synthesized DOXC and TPGS. They showed a high drug loading of hydrophobic DOXC (29%), a size of <100 nm and a pH sensitive drug release behaviour. , fast uptake of DOXC-TOS-TPGS micelles by GL261 cells was observed. For cytotoxicity, DOXC-TOS-TPGS micelles were evaluated on two glioblastoma cell lines and showed synergism between DOXC and TOS-TPGS The higher cytotoxicity of DOXC-TOS-TPGS micelles was mainly caused by necrosis. The DOXC-TOS-TPGS micelles seem to be a promising delivery system for enhancing the anticancer efficacy of doxorubicin in glioblastoma (GBM).

摘要

我们推测，琥珀酸生育酚（TOS）和聚乙二醇2000琥珀酸D-α-生育酚（TPGS）胶束可作为一种药物递送系统，同时增强阿霉素月桂酰腙衍生物（DOXC）治疗胶质母细胞瘤的抗癌疗效。DOXC-TOS-TPGS胶束由合成的DOXC和TPGS配制而成。它们显示出对疏水性DOXC的高载药量（29%）、小于100纳米的粒径以及pH敏感的药物释放行为。观察到GL261细胞对DOXC-TOS-TPGS胶束的快速摄取。对于细胞毒性，在两种胶质母细胞瘤细胞系上评估了DOXC-TOS-TPGS胶束，结果显示DOXC与TOS-TPGS之间具有协同作用。DOXC-TOS-TPGS胶束较高的细胞毒性主要由坏死引起。DOXC-TOS-TPGS胶束似乎是一种有前景的递送系统，可增强阿霉素在胶质母细胞瘤（GBM）中的抗癌疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/ad3655c10526/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/ccaa51e684d0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/f7b0346db0df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/5e10218f0e77/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/a33edcb4a02c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/19289d4808bc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/6e800f91f089/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/10df2e222e9c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/ad3655c10526/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/ccaa51e684d0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/f7b0346db0df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/5e10218f0e77/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/a33edcb4a02c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/19289d4808bc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/6e800f91f089/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/10df2e222e9c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d73/9813532/ad3655c10526/gr7.jpg

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引用本文的文献

[1]
Current Non-Metal Nanoparticle-Based Therapeutic Approaches for Glioblastoma Treatment.

Biomedicines. 2024-8-11

[2]
Metabolic reprogramming of poly(morpho)nuclear giant cells determines glioblastoma recovery from doxorubicin-induced stress.

J Transl Med. 2024-8-12

[3]
Local delivery of doxorubicin prodrug via lipid nanocapsule-based hydrogel for the treatment of glioblastoma.

Drug Deliv Transl Res. 2024-12

本文引用的文献

[1]
pH-Responsive Polymer Nanomaterials for Tumor Therapy.

Front Oncol. 2022-3-22

[2]
Design of Bio-Responsive Hyaluronic Acid-Doxorubicin Conjugates for the Local Treatment of Glioblastoma.

Pharmaceutics. 2022-1-5

[3]
Rationally designed drug delivery systems for the local treatment of resected glioblastoma.

Adv Drug Deliv Rev. 2021-10

[4]
Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo.

J Mater Chem B. 2016-5-21

[5]
Effect of cosurfactant addition on phase behavior and microstructure of a water dilutable microemulsion.

Colloids Surf B Biointerfaces. 2019-12-17

[6]
Experimental models and tools to tackle glioblastoma.

Dis Model Mech. 2019-9-6

[7]
Targeted pharmacokinetics of polymeric micelles modified with glycyrrhetinic acid and hydrazone bond in H22 tumor-bearing mice.

J Biomater Appl. 2019-7

[8]
A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape.

Front Pharmacol. 2019-1-24

[9]
Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment.

Int J Pharm. 2019-1-28

[10]
Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles.

Nanoscale Res Lett. 2018-10-25

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