Foroozandeh Parisa, Aziz Azlan Abdul
School of Physics, Universiti Sains Malaysia, 11800, Gelugor, Penang, Malaysia.
Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Gelugor, Penang, Malaysia.
Nanoscale Res Lett. 2018 Oct 25;13(1):339. doi: 10.1186/s11671-018-2728-6.
Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. However, despite the tremendous benefit conferred, common pitfalls of this technology is its potential short and long-term effects on the human body. To understand these issues, many scientific studies have been carried out. This review attempts to shed light on some of these studies and its outcomes. The topics that were examined in this review include the different possible uptake pathways of nanoparticles and intracellular trafficking routes. Additionally, the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanoparticles are also addressed.
纳米粒子科学正在迅速改变各个科学领域的格局，并定义新的技术平台。这在纳米医学领域可能更为明显，在该领域中，纳米粒子已被用作治疗和诊断许多疾病的工具。然而，尽管带来了巨大益处，但这项技术的常见缺陷是其对人体可能产生的短期和长期影响。为了理解这些问题，已经开展了许多科学研究。本综述试图阐明其中一些研究及其结果。本综述中探讨的主题包括纳米粒子不同的可能摄取途径和细胞内运输途径。此外，还讨论了纳米粒子的物理化学性质（如大小、形状、电荷和表面化学）在确定纳米粒子摄取机制和生物学功能方面的作用。
