Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Turk J Gastroenterol. 2023 Feb;34(2):170-176. doi: 10.5152/tjg.2023.21768.
The aim of this study is to assess levels of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in primary biliary cholangitis patients and excavate their clinical significance.
The levels of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in the primary biliary cholangitis, autoimmune hepatitis, and healthy controls were compared, and correlations between monocyte-to-lymphocyte ratio, red cell distribution width-to-lymphocyte ratio, and Mayo score were analyzed. The area under the receiver operating characteristic curve was utilized to analyze the diagnostic value of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio for primary biliary cholangitis.
Monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in primary biliary cholangitis were higher than they were in autoimmune hepatitis and healthy controls (each, P < .05). Area under the s of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in diagnosis of primary biliary cholangitis were 0.821 and 0.797, respectively (each, P < .001). The combination of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio increased the diagnostic value of primary biliary cholangitis (area under the receiver operating characteristic curve = 0.868, P < .001). The correlation analysis showed that monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio were positively correlated with Mayo score (r-MLR = 0.459, r-RLR = 0.522, P < .001 for each). Red cell distribution width-to-lymphocyte ratio was independently associated with Mayo score (P = .036) by multiple linear regression. In primary biliary cholangitis patients with Child-Pugh classification, monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio levels in class B and class C were significantly higher than in class A (each, P < .05).
Elevated levels of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio may prove to be useful markers for estimating the prognosis of primary biliary cholangitis, and the combined detection of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio has some clinical diagnostic value in patients with primary biliary cholangitis.
本研究旨在评估原发性胆汁性胆管炎患者单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值的水平，并探讨其临床意义。
比较原发性胆汁性胆管炎、自身免疫性肝炎和健康对照组的单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值，并分析单核细胞与淋巴细胞比值、红细胞分布宽度与淋巴细胞比值与 Mayo 评分的相关性。采用受试者工作特征曲线下面积分析单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值对原发性胆汁性胆管炎的诊断价值。
原发性胆汁性胆管炎患者的单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值均高于自身免疫性肝炎和健康对照组（均 P <.05）。单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值诊断原发性胆汁性胆管炎的曲线下面积分别为 0.821 和 0.797（均 P <.001）。单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值联合诊断原发性胆汁性胆管炎的诊断价值增加（曲线下面积=0.868，P <.001）。相关性分析显示，单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值与 Mayo 评分呈正相关（r-MLR=0.459，r-RLR=0.522，均 P <.001）。多元线性回归分析显示，红细胞分布宽度与淋巴细胞比值与 Mayo 评分独立相关（P =.036）。在原发性胆汁性胆管炎患者的 Child-Pugh 分级中，B 级和 C 级患者的单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值明显高于 A 级（均 P <.05）。
单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值升高可能有助于评估原发性胆汁性胆管炎的预后，联合检测单核细胞与淋巴细胞比值和红细胞分布宽度与淋巴细胞比值对原发性胆汁性胆管炎患者具有一定的临床诊断价值。
