Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Nanning, Guangxi , China.
Medicine (Baltimore). 2023 Oct 13;102(41):e35454. doi: 10.1097/MD.0000000000035454.
This study aimed to evaluate the clinical value of the monocyte to high-density lipoprotein cholesterol ratio (MHR) and alkaline phosphatase-to-platelet ratio (APPR) in the diagnosis and prognosis of primary biliary cholangitis (PBC). Clinical and laboratory data were retrospectively collected and analyzed from 92 PBC patients, 92 patients with autoimmune hepatitis (AIH), 120 patients with chronic hepatitis B (CHB) and 124 healthy controls (HCs). We compared the levels of MHR and APPR among the groups with PBC, AIH, CHB and HCs, and analyzed the correlations between MHR and APPR with laboratory indices including aspartate aminotransferase platelet ratio index, fibrosis index based on 4 factors, and Mayo score in PBC. Receiver operating characteristic curves were used to analyze the diagnostic performance of MHR and APPR for PBC, AIH, and CHB, respectively. MHR and APPR were significantly increased in PBC group than that in AIH, CHB and HCs groups (each P < .05). MHR and APPR were significantly higher in Child class B|C than that in class A in PBC patients. (P < .01, P < .05, respectively). MHR and APPR were positively related to the Mayo score [R = 0.508 (P < .001), R = 0.295 (P = .008), respectively]. The area under the receiver operating characteristic curves of MHR and APPR in diagnosing PBC were 0.764 (95% confidence interval [CI]: 0.699-0.821, P < .001) and 0.952 (95% CI: 0.915-0.977, P < .001), respectively, and the area under the curve of the combination of both was 0.974 (95% CI: 0.941-0.991, P < .001). MHR and APPR may prove to be useful prognostic biomarkers for PBC, and the combination of MHR and APPR have some clinical diagnostic value of PBC.
本研究旨在评估单核细胞/高密度脂蛋白胆固醇比值（MHR）和碱性磷酸酶/血小板比值（APPR）在原发性胆汁性胆管炎（PBC）诊断和预后中的临床价值。回顾性收集并分析了 92 例 PBC 患者、92 例自身免疫性肝炎（AIH）患者、120 例慢性乙型肝炎（CHB）患者和 124 例健康对照者（HCs）的临床和实验室数据。比较了 MHR 和 APPR 在 PBC、AIH、CHB 和 HCs 组之间的水平，并分析了 MHR 和 APPR 与包括天冬氨酸转氨酶血小板比值指数、基于 4 个因素的纤维化指数和 PBC 的 Mayo 评分在内的实验室指标之间的相关性。受试者工作特征曲线用于分析 MHR 和 APPR 对 PBC、AIH 和 CHB 的诊断性能。PBC 组的 MHR 和 APPR 明显高于 AIH、CHB 和 HCs 组（均 P <.05）。PBC 患者中，Child 分级 B|C 组的 MHR 和 APPR 明显高于 A 级（均 P <.01，P <.05）。MHR 和 APPR 与 Mayo 评分呈正相关[R = 0.508（P <.001），R = 0.295（P =.008）]。MHR 和 APPR 诊断 PBC 的受试者工作特征曲线下面积分别为 0.764（95%置信区间[CI]：0.699-0.821，P <.001）和 0.952（95%CI：0.915-0.977，P <.001），两者联合的曲线下面积为 0.974（95%CI：0.941-0.991，P <.001）。MHR 和 APPR 可能是 PBC 有用的预后生物标志物，MHR 和 APPR 的联合具有一定的 PBC 临床诊断价值。
