Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Faculty of Psychology, Southwest University (SWU), Chongqing 400715, China.
Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China; Faculty of Psychology, Southwest University (SWU), Chongqing 400715, China; Southwest University Branch, Collaborative Innovation Center of Assessment Toward Basic Education Quality at Beijing Normal University, China.
J Affect Disord. 2023 Mar 15;325:14-21. doi: 10.1016/j.jad.2023.01.015. Epub 2023 Jan 6.
The transition from late adolescence to early adulthood is a period that experiences a surge of life changes and brain reorganization caused by internal and external factors, including negative affect, personality, and social conditions.
Non-imaging phenotype and structural brain variables were available on 497 healthy participants (279 females and 218 males) between 17 and 22 years old. We used sparse canonical correlation analysis (sCCA) on the high-dimensional and longitudinal data to extract modes with maximum covariation between structural brain changes and negative affect, personality, and social conditions.
Separate sCCAs for cortical volume, cortical thickness, cortical surface area and subcortical volume confirmed that each imaging phenotype was correlated with non-imaging features (sCCA |r| range: 0.21-0.38, all p < 0.01). Bilateral superior frontal, left caudal anterior cingulate and bilateral caudate had the highest canonical cross-loadings (|ρ| = 0.15-0.32). In longitudinal data analysis, scan-interval, negative affect, and enthusiasm had the highest association with structural brain changes (|ρ| = 0.07-0.38); at baseline, intellect and politeness were associated with individual variability in the structural brain (|ρ| = 0.10-0.25).
The present study used non-imaging variables only at baseline, making it impossible to explore the relationship between changing behavior and structural brain development.
Individual structural brain changes are associated with multiple factors. In addition to time-dependent variables, we find that negative affect, enthusiasm and social support play a numerically weak but significant role in structural brain development during the transition from late adolescence to young adulthood.
从青少年晚期到成年早期的过渡时期是一个经历内部和外部因素（包括负性情绪、个性和社会条件）引起的生命变化和大脑重组激增的时期。
在 17 至 22 岁的 497 名健康参与者（279 名女性和 218 名男性）中，获得了非成像表型和结构脑变量。我们使用高维纵向数据的稀疏典型相关分析（sCCA），从结构脑变化与负性情绪、个性和社会条件之间的最大协变中提取模式。
皮质体积、皮质厚度、皮质表面积和皮质下体积的单独 sCCA 证实，每种成像表型都与非成像特征相关（sCCA |r| 范围：0.21-0.38，均 p<0.01）。双侧额上回、左侧扣带回后极和双侧尾状核具有最高的典型交叉负荷（|ρ|=0.15-0.32）。在纵向数据分析中，扫描间隔、负性情绪和热情与结构脑变化的相关性最高（|ρ|=0.07-0.38）；在基线时，智力和礼貌与结构脑的个体变异性相关（|ρ|=0.10-0.25）。
本研究仅在基线时使用非成像变量，因此无法探讨行为变化与结构脑发育之间的关系。
个体结构脑变化与多种因素相关。除了时变变量外，我们还发现负性情绪、热情和社会支持在青少年晚期到成年早期的过渡时期对结构脑发育起着数值上微弱但显著的作用。
