Lanzhou University Second Hospital, Lanzhou 730030, China.
Lanzhou University Second Hospital, Lanzhou 730030, China; Gansu Provincial Key Laboratory of Digestive System Cancer, Lanzhou 730030, China.
Photodiagnosis Photodyn Ther. 2023 Mar;41:103271. doi: 10.1016/j.pdpdt.2022.103271. Epub 2023 Jan 6.
Gastrointestinal cancer is a malignant tumor of the gastrointestinal tract and its associated digestive organs, including esophageal cancer, gastric cancer, carcinoma of the ampulla, pancreas, bile duct, intestines and rectal cancer. They account for about 30% of global cancer-related incidence and about 40% of mortality. Photodynamic therapy (PDT), as a treatment mode, has been applied to the treatment of gastrointestinal cancer due to potential advantages targeting and potentially lower toxic side effects. However, In the course of clinical treatment, we have found that different patients have various responsiveness to PDT, and even the same patients may have different clinical effects after receiving treatment in different time periods. For influencing factors, traditionally, we only focus on adjusting the dose of photosensitizer and the intensity and time of irradiation,while minimizing other potential factors.Therefore, this paper looks for factors that affect PDT from the patient's own conditions, tumor characteristics and tumor microenvironment(including:tumor acidic microenvironment,tumor hypoxic microenvironment, multi-drug resistance, different tumor characteristics and the immune status of patients) and summarizes how to potentially improve the curative effect of PDT.
胃肠道癌是胃肠道及其相关消化器官的恶性肿瘤，包括食管癌、胃癌、壶腹癌、胰腺、胆管、肠和直肠癌。它们约占全球癌症相关发病率的 30%，死亡率的 40%。光动力疗法（PDT）作为一种治疗模式，由于具有靶向作用和潜在较低的毒性副作用，已被应用于胃肠道癌的治疗。然而，在临床治疗过程中，我们发现不同的患者对 PDT 有不同的反应，甚至同一患者在不同时期接受治疗后也可能有不同的临床效果。对于影响因素，传统上，我们只关注调整光敏剂的剂量以及照射的强度和时间，而最小化其他潜在因素。因此，本文从患者自身状况、肿瘤特征和肿瘤微环境（包括：肿瘤酸性微环境、肿瘤缺氧微环境、多药耐药性、不同肿瘤特征和患者的免疫状态）寻找影响 PDT 的因素，并总结如何潜在地提高 PDT 的疗效。
