Puolakkainen P, Schröder T
Second Department of Surgery, Helsinki University Central Hospital, Finland.
Dig Dis. 1992;10(1):53-60. doi: 10.1159/000171344.
Photodynamic therapy (PDT) is a new modality of cancer treatment. It consists of intravenously injecting a patient with a photosensitizing agent and, when this agent has accumulated in tumor cells, decomposing it by exposure to red light produced by an argon dye laser. Toxic compounds produced in this reaction then destroy the malignant cells, while normal tissue is not significantly affected. Most clinical experience with PDT has been gained in the treatment of lung cancer, cancer of the urinary bladder and malignancies of the head and neck region. In gastroenterology, esophageal, gastric and colonic tumors have clinically been treated with PDT. This paper is to review the current use of PDT in the treatment of gastrointestinal tumors.
光动力疗法（PDT）是一种新型癌症治疗方法。它包括给患者静脉注射一种光敏剂，当这种药物在肿瘤细胞中蓄积后，通过氩染料激光产生的红光照射将其分解。此反应产生的有毒化合物随后会破坏恶性细胞，而正常组织不会受到明显影响。PDT的大部分临床经验来自于肺癌、膀胱癌以及头颈部恶性肿瘤的治疗。在胃肠病学领域，食管癌、胃癌和结肠癌已采用PDT进行临床治疗。本文旨在综述PDT目前在胃肠道肿瘤治疗中的应用。
