Squire C R, Gimlette T M
Department of Nuclear Medicine, Royal Liverpool Hospital, UK.
Ann Clin Biochem. 1987 Jul;24 ( Pt 4):419-25. doi: 10.1177/000456328702400412.
An enhanced immunochemiluminometric assay for serum TSH ('Amerlite', Amersham, Bucks, UK) was studied in 1127 patients in routine clinical practice to assess its value as a first-line test of thyroid status. Good correlation with clinical thyroid status was found in the untreated euthyroid patients, in the untreated hyperthyroid and hypothyroid patients, in pregnancy and in the sick euthyroid. However, a large proportion of clinically euthyroid patients with nodular goitre, as well as those treated by thyroidectomy, radioiodine or antithyroid drugs and those on replacement l-thyroxine showed TSH values outside the reference range. Therefore, additional tests are likely to be needed frequently in these categories.
在1127例常规临床实践患者中研究了一种用于血清促甲状腺激素的增强免疫化学发光测定法（“Amerlite”，英国白金汉郡阿默舍姆市的安进公司），以评估其作为甲状腺状态一线检测方法的价值。在未经治疗的甲状腺功能正常患者、未经治疗的甲状腺功能亢进和减退患者、妊娠患者以及患病的甲状腺功能正常患者中，发现该方法与临床甲状腺状态具有良好的相关性。然而，很大一部分患有结节性甲状腺肿的临床甲状腺功能正常患者，以及接受甲状腺切除术、放射性碘治疗或抗甲状腺药物治疗的患者和接受左甲状腺素替代治疗的患者，其促甲状腺激素值超出参考范围。因此，在这些类别中可能经常需要进行额外的检测。
