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Thromboblastic hyperthyroidism: sensitive monoclonal TSH assay demonstrates suppressed immunoreactive TSH.

作者信息

Abuaisha B, Barrett E, O'Hare J

机构信息

Department of Medicine, Limerick Regional Hospital, Dooradoyle.

出版信息

Ir J Med Sci. 1991 Mar;160(3):96-7. doi: 10.1007/BF02947265.

DOI:10.1007/BF02947265
PMID:1917429
Abstract

We describe a case of frank clinical hyperthyroidism due to hydatidiform mole. This is thought to be due to human chorionic gonadotrophin (hCG) or a closely related molecule produced by the tumour. hCG can cross-react with TSH in older TSH radioimmunoassays causing falsely elevated TSH levels. We demonstrate this does not occur with a chemiluminescent immunometric (monoclonal) TSH assay despite circulating hCG levels greater than 10(6) u/L.

摘要

相似文献

1
Thromboblastic hyperthyroidism: sensitive monoclonal TSH assay demonstrates suppressed immunoreactive TSH.
Ir J Med Sci. 1991 Mar;160(3):96-7. doi: 10.1007/BF02947265.
2
Incomplete mole with a false-low level of human chorionic gonadotropin and hyperthyroidism.人绒毛膜促性腺激素水平假性降低及甲状腺功能亢进的不完全性葡萄胎。
Acta Obstet Gynecol Scand. 2007;86(5):633-5. doi: 10.1080/00016340600618096.
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Thyroid function and human chorionic gonadotropin in patients with hydatidiform mole.葡萄胎患者的甲状腺功能与人类绒毛膜促性腺激素
J Med Assoc Thai. 1997 Nov;80(11):693-9.
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The human chorionic gonadotropin molecule from patients with trophoblastic diseases has a high thyrotropic activity but is less active in the ovary.来自滋养层疾病患者的人绒毛膜促性腺激素分子具有较高的促甲状腺活性，但在卵巢中的活性较低。
Gynecol Endocrinol. 2004 May;18(5):269-77. doi: 10.1080/09513590410001667247.
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[Hyperthyroidism induced by molar pregnancy].葡萄胎妊娠所致甲状腺功能亢进症
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[Serum TSH levels in normal pregnant women and patients with hydatidiform mole and influence of HCG on TSH immunoradiometric assay].[正常孕妇及葡萄胎患者血清促甲状腺激素水平及人绒毛膜促性腺激素对促甲状腺激素免疫放射测定的影响]
Kaku Igaku. 1988 Jan;25(1):89-96.
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Hyperthyroidism in gestational trophoblastic neoplasia.妊娠滋养细胞肿瘤中的甲状腺功能亢进症。
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Hyperthyroidism and a negative urine hCG test in molar pregnancy.葡萄胎妊娠合并甲状腺功能亢进及尿hCG检测阴性
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Increased in vitro thyrotropic activity of partially sialated human chorionic gonadotropin extracted from hydatidiform moles of patients with hyperthyroidism.
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本文引用的文献

1
Increased thyroid function without clinical hyperthyroidism in patients with choriocarcinoma.绒毛膜癌患者甲状腺功能增强但无临床甲亢表现。
J Clin Endocrinol Metab. 1963 Jul;23:658-64. doi: 10.1210/jcem-23-7-658.
2
Hydatidiform mole--a cause of clinical hyperthyroidism. Report of two cases with evidence that the molar tissue secreted a thyroid stimulator.葡萄胎——临床甲状腺功能亢进的一个病因。两例报告及证据表明葡萄胎组织分泌甲状腺刺激物。
N Engl J Med. 1971 Mar 18;284(11):573-7. doi: 10.1056/NEJM197103182841103.
3
Components of the total serum thyroid hormone concentrations during pregnancy: high free thyroxine and blunted thyrotropin (TSH) response to TSH-releasing hormone in the first trimester.
孕期总血清甲状腺激素浓度的组成部分：孕早期游离甲状腺素水平升高，促甲状腺激素（TSH）对促甲状腺激素释放激素的反应减弱。
J Clin Endocrinol Metab. 1985 Apr;60(4):678-84. doi: 10.1210/jcem-60-4-678.
4
Assessment of an enhanced chemiluminescent immunometric assay for TSH in 1127 patients.对1127例患者进行促甲状腺激素增强化学发光免疫分析检测
Ann Clin Biochem. 1987 Jul;24 ( Pt 4):419-25. doi: 10.1177/000456328702400412.
5
Human chorionic gonadotropin stimulates iodide uptake, adenylate cyclase, and deoxyribonucleic acid synthesis in cultured rat thyroid cells.人绒毛膜促性腺激素刺激培养的大鼠甲状腺细胞摄取碘、激活腺苷酸环化酶并促进脱氧核糖核酸合成。
J Clin Endocrinol Metab. 1988 Jul;67(1):74-9. doi: 10.1210/jcem-67-1-74.
6
Thyroid function in trophoblastic disease.滋养细胞疾病中的甲状腺功能。
Br J Obstet Gynaecol. 1987 Nov;94(11):1084-8. doi: 10.1111/j.1471-0528.1987.tb02294.x.