与年龄和阿尔茨海默病相关的神经原纤维缠结中的胆碱酯酶。
Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease.
作者信息
Mesulam M M, Asuncion Morán M
机构信息
Bullard and Denny-Brown Laboratories, Harvard Neurology Department, Boston, MA 02215.
出版信息
Ann Neurol. 1987 Aug;22(2):223-8. doi: 10.1002/ana.410220206.
PMID:3662453
Abstract
Enzyme histochemistry showed that a substantial number of cortical neurofibrillary tangles contain acetylcholinesterase and butyrylcholinesterase activities in patients with Alzheimer's disease and in nondemented aged individuals. In some areas of the brain, tangles containing each of these two enzymes were differentially distributed. In other areas, there was a very close overlap between the two types of cholinesterase.
摘要
酶组织化学显示，在阿尔茨海默病患者和非痴呆老年人中，大量皮质神经原纤维缠结含有乙酰胆碱酯酶和丁酰胆碱酯酶活性。在大脑的某些区域，含有这两种酶的缠结分布不同。在其他区域，这两种胆碱酯酶之间有非常紧密的重叠。
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