阿尔茨海默病大脑皮质中胆碱酯酶的特殊性质。
Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease.
作者信息
Geula C, Mesulam M
机构信息
Bullard and Denny-Brown Laboratories, Department of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215.
出版信息
Brain Res. 1989 Sep 25;498(1):185-9. doi: 10.1016/0006-8993(89)90419-8.
PMID:2790472
Abstract
Selective cholinesterase inhibitors such as BW284C51 and iso-OMPA showed that the plaques and tangles of Alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity.
摘要
选择性胆碱酯酶抑制剂如BW284C51和异-OMPA表明，阿尔茨海默病的斑块和缠结含有乙酰胆碱酯酶和丁酰胆碱酯酶活性。与正常大脑的胆碱酯酶相比，阿尔茨海默病中与斑块和缠结结合的胆碱酯酶在最适pH值和抑制剂敏感性方面有重大变化。
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