Kogan E A, Ermolenko V M
Arkh Patol. 1987;49(6):66-8.
A case report of a renal (mixed) cell carcinoma found in a 35-year-old male with acquired renal polycystosis who had died from chronic renal insufficiency treated with chronic hemodialysis is presented. The morphogenesis and pathogenesis of acquired polycystic transformation of the kidneys in patients with chronic renal failure and the possible relation of the former to renal cell carcinoma are discussed. A preblastomogenic role is suggested for sclerotic changes arising in polycystic kidneys as well as for hepatitis B virus which may act as an oncogene.
本文报告一例35岁男性患者，其患有获得性肾囊肿病，死于慢性肾功能不全并接受长期血液透析治疗，尸检发现肾（混合）细胞癌。文中讨论了慢性肾衰竭患者肾脏获得性多囊性改变的形态发生和发病机制，以及前者与肾细胞癌的可能关系。提示多囊肾中的硬化性改变以及可能作为致癌基因的乙型肝炎病毒具有成瘤前作用。
