Chaudhuri Amrita, Singha Tara, Jena Bikash Chandra, Shee Maniklal, Datta Prasanta Kumar, Mandal Mahitosh, Singh N D Pradeep
Department of Chemistry, Indian Institute of Technology Kharagpur, 721302, West Bengal, India.
Department of Physics, Indian Institute of Technology Kharagpur, 721302, West Bengal, India.
Chem Commun (Camb). 2023 Jan 26;59(9):1177-1180. doi: 10.1039/d2cc05768a.
Light-activated HS donors have attracted considerable interest in understanding the physiological role and clinical potential of HS, as their release is highly localized and controlled. Herein, we have evolved a new HPQ chromophore-based fluorescent organic nanosystem localized in a target area that tolerates oxidative stress and precisely releases HS under one- and two-photon irradiation with real-time monitoring capability. The two-photon absorption cross-section of this new phototrigger was calculated to be 283 GM at 720 nm. HS photorelease was also demonstrated on the MDA-MB-468 cell line in the presence of excess ROS. Our developed HS nanoprodrug can be applied to living systems to release the HS-gasotransmitter under laser irradiation in a phototherapeutic window.
光激活的硫化氢供体因其释放具有高度局部性和可控性，在理解硫化氢的生理作用和临床潜力方面引起了相当大的兴趣。在此，我们研发了一种基于新型羟基苯基喹啉发色团的荧光有机纳米系统，该系统定位于目标区域，能够耐受氧化应激，并在单光子和双光子照射下精确释放硫化氢，同时具备实时监测能力。计算得出这种新型光触发器在720nm处的双光子吸收截面为283GM。在存在过量活性氧的情况下，还在MDA-MB-468细胞系上证明了硫化氢的光释放。我们研发的硫化氢纳米前药可应用于生物系统，在光疗窗口的激光照射下释放硫化氢气体递质。
