Al-Jubury K S, K O Abdulmunem, Alshareef D K J, Al-Jubury M, Jameel M I
Iraqi Ministry of Health, Baghdad Medical City, Training and Human Development Center, Baghdad, Iraq.
University College Dublin, College of Science, Dublin, Ireland.
Braz J Biol. 2023 Jan 6;84:e266823. doi: 10.1590/1519-6984.266823. eCollection 2023.
On March 11, 2020, the World Health Organization (WHO) declared a new coronavirus infection caused by the SARS-CoV-2 virus as a pandemic, making it the 11th pandemic of the 20th and 21st centuries. This study investigated the clinical and laboratory results (D-dimer, conventional coagulation, and HbA1c biomarker concentrations) of 150 patients (75 male and 75 female) with confirmed COVID-19 pneumonia and 50 controls (25 male and 25 female). For disease diagnosis, all COVID-19 patients were given a Real-Time Reverse Transcription Polymerase Chain Reaction Assay (RT-PCR). The findings revealed that D-dimer and HbA1c levels in COVID-19 patients were significantly higher (P 0.001) at the time of admission; In COVID-19 patients, there was also a strong correlation between D-dimer levels and HbA1c levels (P 0.001). In conclusion, COVID-19 patients are more likely to have a poor prognosis if their D-dimer and HbA1c levels remain uncontrolled over a lengthy period. To lower the likelihood of a bad prognosis in COVID-19, patients with higher levels of D-dimer and HbA1c should be continuously monitored.
2020年3月11日，世界卫生组织（WHO）宣布由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引起的新型冠状病毒感染为大流行病，使其成为20世纪和21世纪的第11次大流行。本研究调查了150例确诊为新冠肺炎的患者（75例男性和75例女性）和50例对照者（25例男性和25例女性）的临床和实验室检查结果（D-二聚体、常规凝血指标和糖化血红蛋白生物标志物浓度）。为进行疾病诊断，所有新冠肺炎患者均接受了实时逆转录聚合酶链反应检测（RT-PCR）。研究结果显示，新冠肺炎患者入院时D-二聚体和糖化血红蛋白水平显著升高（P<0.001）；在新冠肺炎患者中，D-二聚体水平与糖化血红蛋白水平之间也存在强相关性（P<0.001）。总之，如果新冠肺炎患者的D-二聚体和糖化血红蛋白水平长期得不到控制，其预后更有可能较差。为降低新冠肺炎患者预后不良的可能性，应对D-二聚体和糖化血红蛋白水平较高的患者进行持续监测。
