Garcia Nicole, Lau Lachlan Dat Wah, Lo Cheng Hean, Cleland Heather, Akbarzadeh Shiva
Skin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, Victoria, Australia.
Department of Surgery, Monash University, 99 Commercial Road, Melbourne, Victoria, Australia.
J Wound Care. 2023 Jan 2;32(1):55-62. doi: 10.12968/jowc.2023.32.1.55.
Spontaneous wound repair is a complex process that involves overlapping phases of inflammation, proliferation and remodelling, co-ordinated by growth factors and proteases. In extensive wounds such as burns, the repair process would not be achieved in a timely fashion unless grafted. Although spontaneous wound repair has been extensively described, the processes by which wound repair mechanisms mediate graft take are yet to be fully explored. This review describes engraftment stages and summarises current understanding of molecular mechanisms which regulate autologous skin graft healing, with the goal of directing innovation in permanent wound closure with skin substitutes. Graftability and vascularisation of various skin substitutes that are either in the market or in development phase are discussed. In doing so, we cast a spotlight on the paucity of scientific information available as to how skin grafts (both autologous and engineered) heal a wound bed. Better understanding of these processes may assist in developing novel methods of wound management and treatments.
自发性伤口修复是一个复杂的过程，涉及炎症、增殖和重塑等相互重叠的阶段，由生长因子和蛋白酶协调。在大面积伤口如烧伤中，除非进行移植，否则修复过程无法及时完成。尽管自发性伤口修复已被广泛描述，但伤口修复机制介导移植成功的过程尚未得到充分探索。本综述描述了移植阶段，并总结了目前对调节自体皮肤移植愈合的分子机制的理解，目的是指导皮肤替代物在永久性伤口闭合方面的创新。讨论了市场上或处于研发阶段的各种皮肤替代物的可移植性和血管化情况。通过这样做，我们聚焦于关于皮肤移植（自体和工程化）如何愈合伤口床的科学信息匮乏这一问题。更好地理解这些过程可能有助于开发新的伤口管理和治疗方法。
