Shakespeare P
Laing Laboratory for Burn Injury Investigation, Salisbury District Hospital, Wiltshire, SP2 8BJ, Salisbury, UK.
Burns. 2001 Aug;27(5):517-22.
Burn wound healing is a complex process in the biological objectives and mechanisms defined by the initial injury. In this paper the use of keratinocytes as a skin substitute is used to illustrate some of the problems associated with the development and use of skin substitutes. Skin substitute development must always be viewed against the biological and clinical background in order to provide maximum assistance to the challenging task of treating burn wounds.
烧伤创面愈合是一个在由初始损伤所定义的生物学目标和机制方面的复杂过程。在本文中，角质形成细胞作为皮肤替代物的应用被用来阐释与皮肤替代物的开发和使用相关的一些问题。皮肤替代物的开发必须始终结合生物学和临床背景来考量，以便为治疗烧伤创面这一具有挑战性的任务提供最大程度的帮助。
