A tree-based modeling approach for matched case-control studies.

Conditional logistic regression (CLR) is the indisputable standard method for the analysis of matched case-control studies. However, CLR is strongly restricted with respect to the inclusion of non-linear effects and interactions of confounding variables. A novel tree-based modeling method is proposed which accounts for this issue and provides a flexible framework allowing for a more complex confounding structure. The proposed machine learning model is fitted within the framework of CLR and, therefore, allows to account for the matched strata in the data. A simulation study demonstrates the efficacy of the method. Furthermore, for illustration the method is applied to a matched case-control study on cervical cancer.