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韩国产双歧杆菌阳性艰难梭菌的多样性。

Diversity of binary toxin positive Clostridioides difficile in Korea.

机构信息

Division of Infectious Diseases, Department of Internal Medicine, Hanyang University College of Medicine, 222-1 Wangsimni-Ro, Seongdong-Gu, Seoul, 04763, Korea.

出版信息

Sci Rep. 2023 Jan 11;13(1):576. doi: 10.1038/s41598-023-27768-0.

Abstract

The objective of this study is to determine the trend and diversity of binary toxin-positive Clostridioides difficile over 10 years in Korea. Binary toxin-positive strains were selected from a tertiary hospital in Korea in 2009-2018. The multi-locus sequence typing and antibiotic susceptibility test were performed. Among the 3278 isolates in 2009-2018, 58 possessed binary toxin genes (1.7%). The proportion of CDT- positive isolates was 0.51-4.82% in 2009-2018, which increased over the 10-year period (P = 0.023). Thirteen sequence types (STs) were identified; ST5 (14 [24%]), ST11 (11 [19%]), ST221 (10 [17%]), ST201 (7 [12%]) and ST1 (5 [9%]) were popular. All 58 isolates were susceptible to vancomycin and piperacillin/tazobactam, and clindamycin and moxifloxacin were active in 69.0% and 62% of isolates, respectively. ST1 strains were resistant to several antibiotics, including moxifloxacin (80%), clindamycin (60%) and rifaximin (60%). Moreover, four of five ST1 presented a metronidazole minimum inhibitory concentration of 4 µg/mL. Moxifloxacin resistance was highest (72.3%) for ST11. In conclusion, binary toxin-positive strains are non-prevalent in Korea and involve diverse STs. ST1 strains were resistant to several antibiotics.

摘要

本研究旨在确定 10 年来韩国产二联毒素阳性艰难梭菌的趋势和多样性。从 2009 年至 2018 年,从韩国的一家三级医院中选择了二联毒素阳性菌株。进行了多位点序列分型和抗生素药敏试验。在 2009 年至 2018 年的 3278 株分离株中,有 58 株携带二元毒素基因(1.7%)。2009-2018 年间,CDT 阳性分离株的比例为 0.51-4.82%,呈上升趋势(P=0.023)。共鉴定出 13 种序列型(ST);ST5(14[24%])、ST11(11[19%])、ST221(10[17%])、ST201(7[12%])和 ST1(5[9%])较为流行。所有 58 株分离株均对万古霉素和哌拉西林/他唑巴坦敏感,克林霉素和莫西沙星分别在 69.0%和 62%的分离株中有效。ST1 株对包括莫西沙星(80%)、克林霉素(60%)和利福昔明(60%)在内的几种抗生素均有耐药性。此外,5 株 ST1 中有 4 株的甲硝唑最小抑菌浓度为 4µg/mL。ST11 的莫西沙星耐药率最高(72.3%)。总之,二元毒素阳性菌株在韩国并不常见,涉及多种 ST。ST1 株对几种抗生素均有耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc22/9834304/4ce1d9ef2561/41598_2023_27768_Fig1_HTML.jpg

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