Józefacka Natalia Maja, Machnikowska-Sokołowska Magdalena Dagmara, Kołek Mateusz Franciszek, Gruszczyńska Katarzyna Jadwiga, Musioł Katarzyna
Institute of Psychology, Pedagogical University in Kraków, Krakow, Poland.
Division of Diagnostic Imaging Department of Radiology and Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia Katowice, Katowice, Poland.
Rep Pract Oncol Radiother. 2022 Dec 29;27(6):1037-1044. doi: 10.5603/RPOR.a2022.0105. eCollection 2022.
The aim of the study was to determine the relationship between a damaged cerebellum area and the cognitive performance of medulloblastoma tumour survivors. Also, age-based differences in cognitive performance were tested.
Magnetic resonance imaging (MRI) technique was used to obtain brain images of survivors. The cognitive performance was tested using Wechsler Intelligence Scale for Children Revised (WISC-R) and Wechsler Adult Intelligence Scale (WAIS). Statistical analysis was performed with highly robust permutation tests.
There were two anatomical features strongly influencing the cognitive performance of survivors. The extension of the foramen of Luschka had a negative impact on the overall verbal IQ score and some non-verbal scales while the excision of the middle part of the vermis influenced scores in such scales as arithmetic and picture completing.
Children with postoperative damages in the area of the middle part of the vermis are more likely to suffer from cognitive dysfunctions after the end of the treatment.
本研究的目的是确定髓母细胞瘤肿瘤幸存者小脑受损区域与认知表现之间的关系。此外，还测试了基于年龄的认知表现差异。
使用磁共振成像（MRI）技术获取幸存者的脑部图像。使用韦氏儿童智力量表修订版（WISC-R）和韦氏成人智力量表（WAIS）测试认知表现。采用高度稳健的置换检验进行统计分析。
有两个解剖学特征对幸存者的认知表现有强烈影响。卢施卡孔的扩展对总体言语智商得分和一些非言语量表有负面影响，而蚓部中部的切除影响算术和图片完成等量表的得分。
蚓部中部区域术后受损的儿童在治疗结束后更有可能出现认知功能障碍。
