Department of Psychological Science, University of Central Missouri, Warrensburg, 64093, USA.
J Clin Exp Neuropsychol. 2012;34(6):571-9. doi: 10.1080/13803395.2012.666229. Epub 2012 Mar 7.
Forty patients with relapsing-remitting multiple sclerosis (MS) completed the 10 core Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) subtests. Means for age and education were 42.05 years (SD = 9.94) and 14.33 years (SD = 2.40). For all participants, the native language was English. The mean duration of MS diagnosis was 8.17 years (SD = 7.75), and the mean Expanded Disability Status Scale (EDSS; Kurtzke, 1983 ) score was 3.73 (SD = 1.41) with a range from 2.0 to 6.5. A control group of healthy individuals with similar demographic characteristics also completed the WAIS-IV and were provided by the test publisher. Compared to controls, patients with MS earned significantly lower subtest and composite scores. The patients' mean scores were consistently in the low-average to average range, and the patterns of performance across groups did not differ significantly, although there was a trend towards higher scores on the Verbal Comprehension Index (VCI) and lower scores on the Processing Speed Index (PSI). Approximately 78% of patients had actual Full Scale IQs that were significantly lower than preillness, demographically based IQ estimates.
四十名复发性缓解型多发性硬化症（MS）患者完成了韦氏成人智力量表第四版（WAIS-IV）的 10 项核心子测验。年龄和教育程度的平均值分别为 42.05 岁（标准差=9.94）和 14.33 年（标准差=2.40）。所有参与者的母语均为英语。MS 诊断的平均持续时间为 8.17 年（标准差=7.75），扩展残疾状况量表（EDSS；Kurtzke，1983）的平均得分为 3.73（标准差=1.41），范围为 2.0 至 6.5。具有相似人口统计学特征的健康对照组也完成了 WAIS-IV，由测试出版商提供。与对照组相比，MS 患者的子测验和综合评分明显较低。患者的平均分数始终处于中下等至中等水平，虽然言语理解指数（VCI）的得分较高，而加工速度指数（PSI）的得分较低，但两组之间的表现模式没有显著差异。大约 78%的患者的实际全量表智商明显低于患病前基于人口统计学的智商估计。
