Dudde Florian, Giese Manfred, Henkel Kai-Olaf
Department of Oral and Maxillofacial Surgery, Army Hospital Hamburg, Hamburg, Germany.
Cancer Diagn Progn. 2023 Jan 3;3(1):107-114. doi: 10.21873/cdp.10187. eCollection 2023 Jan-Feb.
BACKGROUND/AIM: The solitary fibrous tumor (SFT) is a mesenchymal neoplasm and belongs to the group of soft tissue sarcomas. The SFT is characterized by indolent, slowly progressive growth and manifests itself clinically by compression of neighboring structures. The treatment of choice is surgical removal of the tumor. In advanced stages, there is also the possibility of chemotherapy, systemic therapy, or immunotherapy, as well as radiotherapy. Depending on their location and severity, SFTs show different recurrence rates and survival functions.
The present case report shows an extremely rare localization of a low-risk SFT in the floor of the mouth. Despite complete surgical removal of the SFT, the patient showed a metastasis of the SFT in the mandible two years postoperatively. Therefore, this case report shows that even a low-risk SFT in the localized stage can metastasize despite of total surgical removal. Consequently, SFTs of the head and neck region require close clinical and imaging follow-up.
Although the localization of the SFT in the oral cavity is a rarity, this entity should be included in the differential diagnosis in the case of long-term space-occupying processes in the head and neck region. This report is the first regarding metastasis of a SFT to the mandible.
背景/目的:孤立性纤维瘤(SFT)是一种间叶性肿瘤,属于软组织肉瘤。SFT的特点是生长缓慢、惰性,临床上表现为对邻近结构的压迫。首选治疗方法是手术切除肿瘤。在晚期,也可进行化疗、全身治疗或免疫治疗以及放疗。根据其位置和严重程度,SFT表现出不同的复发率和生存功能。
本病例报告显示了一例罕见的低风险SFT位于口腔底部。尽管SFT已完全手术切除,但患者在术后两年出现了SFT在下颌骨的转移。因此,本病例报告表明,即使是局部阶段的低风险SFT,尽管已完全手术切除仍可能发生转移。因此,头颈部区域的SFT需要密切的临床和影像学随访。
尽管SFT在口腔中的定位很罕见,但在头颈部区域出现长期占位性病变时,应将该实体纳入鉴别诊断。本报告是首例关于SFT转移至下颌骨的报道。