Barrera Jannis, H Haeri Haleh, Heinrich Julian, Stein Matthias, Hinderberger Dariush, Kulak Nora
Institute of Chemistry, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany.
Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.
Dalton Trans. 2023 Mar 14;52(11):3279-3286. doi: 10.1039/d2dt02044k.
Cu(II) complexes with ATCUN peptide ligands have been investigated for their ROS (reactive oxygen species) generation and oxidative DNA degradation abilities. The biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is, however, low. Tuning the redox chemistry by incorporation of N-heteroaromatics reinstates ROS production which leads to efficient DNA cleavage.
已对铜（II）与ATCUN肽配体形成的配合物的活性氧（ROS）生成能力和氧化DNA降解能力进行了研究。然而，大多数ATCUN配合物，如铜-甘氨酰甘氨酰组氨酸（Cu-GGH）的生物活性较低。通过引入氮杂芳烃来调节氧化还原化学性质可恢复ROS的产生，从而实现高效的DNA切割。
