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Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond.

作者信息

Rivera Angela, Heitman Joseph

机构信息

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

出版信息

PLoS Pathog. 2023 Jan 12;19(1):e1011056. doi: 10.1371/journal.ppat.1011056. eCollection 2023 Jan.

DOI:10.1371/journal.ppat.1011056
PMID:36634035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9836287/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/9836287/9360baf996fd/ppat.1011056.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/9836287/9360baf996fd/ppat.1011056.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/9836287/9360baf996fd/ppat.1011056.g001.jpg

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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.利用侵袭性真菌病原体中的钙调神经磷酸酶-FK506-FKBP12 晶体结构开发抗真菌药物。
Nat Commun. 2019 Sep 19;10(1):4275. doi: 10.1038/s41467-019-12199-1.
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Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.
Geroscience. 2025 Jan 30. doi: 10.1007/s11357-025-01534-8.
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Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi.基于结构导向的C22和C32修饰FK520类似物的设计与合成及其对人类致病真菌活性的增强
Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2419883121. doi: 10.1073/pnas.2419883121. Epub 2024 Dec 31.
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