Fumal A, Timmermans G
Service Universitaire de Neurologie, Centre de Recherche des Céphalées, Hôpital de la Citadelle, Liège, Belgique.
Rev Med Liege. 2023 Jan;78(1):46-54.
Although migraine is one of the most common chronic diseases and is the subject of numerous studies, there is still a considerable proportion of patients who are not satisfied with their acute treatment. Left without any real new therapeutic option to offer patients since sumatriptan was introduced on the Belgian market 30 years ago, neurologists have recently seen a change in the therapeutic landscape with the advent of new specific acute treatments for migraine: gepants and ditans. Being the only ones currently available in Belgium, gepants (including the newly marketed rimegepant) bring added value to traditional treatments such as non-steroidal anti-inflammatory drugs and triptans. This is why it seemed useful to review the different therapeutic options available in Belgium today by including these new treatments and to propose a rational pharmacological approach to relieve acute migraine attack.
尽管偏头痛是最常见的慢性疾病之一,且是众多研究的主题,但仍有相当一部分患者对其急性治疗不满意。自从30年前舒马曲坦在比利时市场推出以来,神经科医生一直没有真正新的治疗选择可以提供给患者,而随着偏头痛新型特异性急性治疗药物—— gepants和ditans的出现,最近治疗格局发生了变化。作为比利时目前仅有的药物,gepants(包括新上市的瑞美吉泮)为非甾体抗炎药和曲坦类等传统治疗带来了附加价值。这就是为什么通过纳入这些新疗法来回顾当今比利时可用的不同治疗选择,并提出一种合理的药理学方法来缓解急性偏头痛发作似乎很有必要。