Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, ON, Canada.
Department of Public Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.
PLoS One. 2023 Jan 12;18(1):e0280308. doi: 10.1371/journal.pone.0280308. eCollection 2023.
Although several epidemiological studies have linked social isolation to increased risk of mortality, the magnitude of any effect is unclear, in part because of the use of different measures of social isolation.
To examine the association between social isolation and all-cause mortality and investigate whether it differs in various subgroups or populations.
We searched for relevant studies in electronic databases: MEDLINE (1946 to December 31, 2021), EMBASE (1974 to December 31, 2021), and PsycINFO (1806 to December 31, 2021).
We included both prospective and retrospective cohort studies that examined the association between social isolation and all-cause mortality among adults.
Two reviewers screened and extracted data independently. We contacted study authors to obtain missing information whenever possible. Data were pooled using a random effect model to calculate estimates of the effects of social isolation on all-cause mortality.
Data from studies involving 1.30 million individuals were included. The pooled hazard ratio of social isolation for all-cause mortality was 1.33 (95% confidence interval; 1.26-1.41, heterogeneity: Chi² = 112.51, P < 0.00001, I² = 76%).
Social isolation is associated with increased risk for all-cause mortality.
PROSPERO (CRD42020152351).
尽管有几项流行病学研究表明社会隔离与死亡率增加有关，但由于使用了不同的社会隔离衡量标准，其影响的程度尚不清楚。
研究社会隔离与全因死亡率之间的关联，并探讨其在不同亚组或人群中的差异。
我们在电子数据库中搜索了相关研究：MEDLINE（1946 年至 2021 年 12 月 31 日）、EMBASE（1974 年至 2021 年 12 月 31 日）和 PsycINFO（1806 年至 2021 年 12 月 31 日）。
纳入了前瞻性和回顾性队列研究，这些研究考察了社会隔离与成年人全因死亡率之间的关联。
两位审查员独立筛选和提取数据。只要有可能，我们就会联系研究作者以获取缺失的信息。使用随机效应模型汇总数据，以计算社会隔离对全因死亡率的影响估计值。
纳入了涉及 130 万人的数据。社会隔离与全因死亡率的汇总风险比为 1.33（95%置信区间，1.26-1.41，异质性：Chi² = 112.51，P < 0.00001，I² = 76%）。
社会隔离与全因死亡率增加有关。
PROSPERO（CRD42020152351）。
