Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil.
Laboratory of Nutrition, Exercise and Health (LaNES), School of Medicine, Federal University of Uberlandia, Minas Gerais, Brazil.
Exp Gerontol. 2023 Mar;173:112084. doi: 10.1016/j.exger.2023.112084. Epub 2023 Jan 9.
To evaluate the association of inflammation (C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) levels) with muscle strength in older adults. We also aimed to evaluate whether these associations are sex-specific. A cross-sectional study was performed with data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2001-2002. A total of 2387 individuals over 50 years of both sexes were evaluated, according to the eligibility criteria for the strength test. Muscle strength was measured by Kinetic Communicator isokinetic dynamometer; while the NLR was obtained by the ratio of the total neutrophil for lymphocyte count and CRP was quantified by latex nephelometry. Linear regression analyses, crude and adjusted for confounders, were used to estimate the coefficients and 95 % confidence intervals for peak strength (muscle strength) by tertiles of NLR and CRP. There was no association between NLR and peak strength for both sexes. CRP levels were inversely associated with peak force in men [2nd tertile β = -3.33 (-15.92; 9.25); 3rd tertile β = -24.69 (-41.18; -8.20), p for trend = 0.005], but not in women [2nd tertile β = -3.22 (-15.00; 8.56); 3rd tertile β = -9.23 (-28.40; -9.94), p for trend = 0.332]. In conclusion, NLR levels were not associated with muscle strength in both sexes. CRP levels were inversely associated with muscle strength in older men, but not in women, suggesting that the association between inflammation and muscle strength in older adults can be sex-specific.
评估炎症（C 反应蛋白（CRP）和中性粒细胞与淋巴细胞比值（NLR）水平）与老年人肌肉力量之间的关系。我们还旨在评估这些关联是否具有性别特异性。本研究采用 1999-2000 年和 2001-2002 年全国健康和营养调查（NHANES）的数据进行了横断面研究。根据力量测试的入选标准，共评估了 2387 名 50 岁以上的男女。肌肉力量通过 Kinetic Communicator 等速测力计测量；而 NLR 通过总中性粒细胞与淋巴细胞计数的比值获得，CRP 通过乳胶比浊法定量。使用线性回归分析、未调整和调整混杂因素，估计 NLR 和 CRP 三分位的峰值强度（肌肉力量）的系数和 95%置信区间。NLR 与两性的峰值强度均无关联。CRP 水平与男性的峰值力呈负相关[第 2 三分位 β = -3.33（-15.92；9.25）；第 3 三分位 β = -24.69（-41.18；-8.20），趋势 p = 0.005]，但在女性中无相关性[第 2 三分位 β = -3.22（-15.00；8.56）；第 3 三分位 β = -9.23（-28.40；-9.94），趋势 p = 0.332]。总之，NLR 水平与两性的肌肉力量均无相关性。CRP 水平与老年男性的肌肉力量呈负相关，但与女性无关，这表明炎症与老年成年人肌肉力量之间的关联可能具有性别特异性。
