Li D F, Wong V C, O'Hoy K M, Ma H K
Department of Obstetrics and Gynaecology, University of Hong Kong.
Br J Obstet Gynaecol. 1987 Sep;94(9):847-50. doi: 10.1111/j.1471-0528.1987.tb03752.x.
A group of pregnant women at high risk of developing diabetes in pregnancy had paired oral glucose tolerance tests (OGTT) using a 100 g load followed by 75 g load. When the World Health Organization (WHO) criteria and the National Diabetes Data Group (NDDG) criteria were compared, the 2-h plasma glucose value after the 100 g load was the most discriminative in differentiating those with normal glucose tolerance, impaired glucose tolerance and gestational diabetes mellitus. When only the 2-h plasma glucose values were assessed, the WHO test (75 g: 8 mmol/l) agreed with the NDDG test (100 g load: 9.2 mmol/l) in the diagnosis of glucose intolerance in 60% of subjects only. Using the same criteria at 2-h (8 mmol/l) the agreement between these tests was 47%. Reducing the glucose load from 100 g to 75 g produced a reduced glucose response in 49% of the subjects, with a significant decrease in the area under the glucose response curve.
一组妊娠糖尿病高危孕妇接受了两次口服葡萄糖耐量试验（OGTT），先给予100克负荷量，随后给予75克负荷量。在比较世界卫生组织（WHO）标准和美国国家糖尿病数据组（NDDG）标准时，100克负荷量后2小时的血浆葡萄糖值在区分糖耐量正常、糖耐量受损和妊娠期糖尿病患者方面最具鉴别力。仅评估2小时血浆葡萄糖值时，WHO试验（75克：8毫摩尔/升）与NDDG试验（100克负荷量：9.2毫摩尔/升）在仅60%的受试者中对葡萄糖不耐受的诊断结果一致。采用相同的2小时标准（8毫摩尔/升）时，这些试验之间的一致性为47%。将葡萄糖负荷量从100克降至75克后，49%的受试者葡萄糖反应降低，葡萄糖反应曲线下面积显著减小。
