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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

van Tonder S V, Ruck A, van der Westhuyzen J, Fernandes-Costa F, Metz J

Department of Haematology, School of Pathology, South African Institute for Medical Research, Johannesburg.

Br J Nutr. 1986 Jan;55(1):187-92. doi: 10.1079/bjn19860022.

The effect of methylcobalamin inactivation by the anaesthetic gas nitrous oxide on the activity of the cobalamin-dependent methionine synthetase (5-methyltetrahydrofolate homocysteine methyltransferase; EC 2.1.1.13) reaction, and on DNA synthesis, in the fruit bat Rousettus aegyptiacus, was examined. 2. Methionine synthetase activity in the liver of bats exposed to N2O-oxygen (50:50, v/v) for 90 min/d averaged 32% of that of controls after 4 d of exposure and only 5% after 12-14 weeks of exposure. 3. DNA synthesis in the bone marrow, as reflected by the deoxyuridine suppression test, was unaffected by 4 d of exposure to N2O and only minimally affected after 5-10 weeks of exposure. 4. These results suggest that DNA synthesis in the fruit bat is unusually resistant to inhibition of methionine synthetase and imply the existence of a non-methylated circulating folate pool in this species.

研究了麻醉气体氧化亚氮使甲钴胺失活对埃及果蝠中钴胺素依赖性甲硫氨酸合成酶（5-甲基四氢叶酸高半胱氨酸甲基转移酶；EC 2.1.1.13）反应活性以及DNA合成的影响。2. 暴露于N₂O-氧气（50:50，v/v）中，每天90分钟，持续4天的蝙蝠肝脏中的甲硫氨酸合成酶活性，平均为对照组的32%；暴露12 - 14周后，仅为对照组的5%。3. 脱氧尿苷抑制试验反映的骨髓中的DNA合成，在暴露于N₂O 4天时未受影响，暴露5 - 10周后仅受到轻微影响。4. 这些结果表明，果蝠中的DNA合成对甲硫氨酸合成酶的抑制具有异常的抗性，这意味着该物种中存在非甲基化的循环叶酸池。

van Tonder S V, Ruck A, van der Westhuyzen J, Fernandes-Costa F, Metz J

Department of Haematology, School of Pathology, South African Institute for Medical Research, Johannesburg.

Br J Nutr. 1986 Jan;55(1):187-92. doi: 10.1079/bjn19860022.

The effect of methylcobalamin inactivation by the anaesthetic gas nitrous oxide on the activity of the cobalamin-dependent methionine synthetase (5-methyltetrahydrofolate homocysteine methyltransferase; EC 2.1.1.13) reaction, and on DNA synthesis, in the fruit bat Rousettus aegyptiacus, was examined. 2. Methionine synthetase activity in the liver of bats exposed to N2O-oxygen (50:50, v/v) for 90 min/d averaged 32% of that of controls after 4 d of exposure and only 5% after 12-14 weeks of exposure. 3. DNA synthesis in the bone marrow, as reflected by the deoxyuridine suppression test, was unaffected by 4 d of exposure to N2O and only minimally affected after 5-10 weeks of exposure. 4. These results suggest that DNA synthesis in the fruit bat is unusually resistant to inhibition of methionine synthetase and imply the existence of a non-methylated circulating folate pool in this species.

研究了麻醉气体氧化亚氮使甲钴胺失活对埃及果蝠中钴胺素依赖性甲硫氨酸合成酶（5-甲基四氢叶酸高半胱氨酸甲基转移酶；EC 2.1.1.13）反应活性以及DNA合成的影响。2. 暴露于N₂O-氧气（50:50，v/v）中，每天90分钟，持续4天的蝙蝠肝脏中的甲硫氨酸合成酶活性，平均为对照组的32%；暴露12 - 14周后，仅为对照组的5%。3. 脱氧尿苷抑制试验反映的骨髓中的DNA合成，在暴露于N₂O 4天时未受影响，暴露5 - 10周后仅受到轻微影响。4. 这些结果表明，果蝠中的DNA合成对甲硫氨酸合成酶的抑制具有异常的抗性，这意味着该物种中存在非甲基化的循环叶酸池。