一氧化二氮对大鼠体内维生素B12的选择性失活作用。
Selective inactivation of vitamin B12 in rats by nitrous oxide.
作者信息
Deacon R, Lumb M, Perry J, Chanarin I, Minty B, Halsey M J, Nunn J F
出版信息
Lancet. 1978 Nov 11;2(8098):1023-4. doi: 10.1016/s0140-6736(78)92341-3.
PMID:82036
Abstract
Exposure of rats to nitrous oxide rapidly inactivated the cytosol enzyme, methionine synthetase, but the mitochondrial enzyme, methylmalonyl CoA mutase, seemed to be unaffected, although both enzymes require vitamin B12.
摘要
将大鼠暴露于一氧化二氮中会迅速使胞质溶胶酶甲硫氨酸合成酶失活，但线粒体酶甲基丙二酰辅酶A变位酶似乎未受影响，尽管这两种酶都需要维生素B12。
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