文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

多胺腐胺是第三组固有淋巴细胞激活的正调节剂。

The Polyamine Putrescine Is a Positive Regulator of Group 3 Innate Lymphocyte Activation.

机构信息

Department of Microbiology and Immunology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

出版信息

Immunohorizons. 2023 Jan 1;7(1):41-48. doi: 10.4049/immunohorizons.2200097.

DOI:10.4049/immunohorizons.2200097
PMID:36637514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10520894/
Abstract

Group 3 innate lymphocytes (ILC3s) rapidly respond to invading pathogens or inflammatory signals, which requires shifting cellular metabolic demands. Metabolic adaptations regulating ILC3 function are not completely understood. Polyamines are polycationic metabolites that have diverse roles in cellular functions and in immunity regulate immune cell biology, including Th17 cells. Whether polyamines play a role in ILC3 activation is unknown. In this article, we report that the polyamine synthesis pathway is important for ILC3 activation. IL-23-activated mouse ILC3s upregulate ornithine decarboxylase, the enzyme catalyzing the rate-limiting step of the conversion of ornithine to putrescine in polyamine synthesis, with a subsequent increase in putrescine levels. Inhibition of ornithine decarboxylase via a specific inhibitor, α-difluoromethylornithine, reduced levels of IL-22 produced by steady-state or IL-23-activated ILC3s in a putrescine-dependent manner. Thus, the polyamine putrescine is a positive regulator of ILC3 activation. Our results suggest that polyamines represent a potential target for therapeutic modulation of ILC3 activation during infection or inflammatory disorders.

摘要

第三组固有淋巴细胞（ILC3）迅速对入侵病原体或炎症信号做出反应，这需要改变细胞的代谢需求。调节 ILC3 功能的代谢适应尚不完全清楚。多胺是带正电荷的代谢物，在细胞功能和免疫调节中具有多种作用，包括调节 Th17 细胞。多胺是否在 ILC3 的激活中起作用尚不清楚。在本文中，我们报告多胺合成途径对 ILC3 的激活很重要。IL-23 激活的小鼠 ILC3 上调鸟氨酸脱羧酶，该酶催化多胺合成中鸟氨酸转化为腐胺的限速步骤，随后腐胺水平增加。通过特异性抑制剂α-二氟甲基鸟氨酸抑制鸟氨酸脱羧酶，以腐胺依赖的方式降低稳态或 IL-23 激活的 ILC3 产生的 IL-22 水平。因此，多胺腐胺是 ILC3 激活的正调节剂。我们的结果表明，多胺代表了感染或炎症性疾病期间调节 ILC3 激活的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/895d9aad0d12/ih2200097f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/79bf2fba328f/ih2200097f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/fff38e0fa3e2/ih2200097f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/921033843dd8/ih2200097f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/895d9aad0d12/ih2200097f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/79bf2fba328f/ih2200097f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/fff38e0fa3e2/ih2200097f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/921033843dd8/ih2200097f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7859/10563397/895d9aad0d12/ih2200097f4.jpg

相似文献

[1]
The Polyamine Putrescine Is a Positive Regulator of Group 3 Innate Lymphocyte Activation.

Immunohorizons. 2023-1-1

[2]
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.

Proc Natl Acad Sci U S A. 2022-11-8

[3]
Increased ornithine decarboxylase activity and polyamine biosynthesis are required for optimal cytolytic T lymphocyte induction.

Cell Immunol. 1987-3

[4]
N-methyl-D-aspartate receptor excitotoxicity involves activation of polyamine synthesis: protection by alpha-difluoromethylornithine.

J Neurochem. 1993-1

[5]
The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine.

Biochem J. 1984-11-15

[6]
Epidermal growth factor: modulator of murine embryonic palate mesenchymal cell proliferation, polyamine biosynthesis, and polyamine transport.

J Cell Physiol. 1989-8

[7]
Differential effects of polyamine homologues on the prevention of DL-alpha-difluoromethylornithine-mediated inhibition of malignant cell growth and normal immune response.

Cancer Res. 1992-4-1

[8]
Regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in a polyamine auxotrophic cell line.

Mol Cell Biochem. 1996-9-20

[9]
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.

J Biol Chem. 2004-6-25

[10]
Polyamines and hypusination are important for toxin B (TcdB)-mediated activation of group 3 innate lymphocytes (ILC3s).

Infect Immun. 2023-11-16

引用本文的文献

[1]
Deciphering the Role of Innate Lymphoid Cells Group 3 in the Gut Microenvironment: A Narrative Review of Their Novel Contributions to Autoimmune Disease Pathogenesis.

J Inflamm Res. 2025-4-28

[2]
Regulation of innate lymphoid cell by microbial metabolites.

J Mol Med (Berl). 2025-5

[3]
Role of polyamines in intestinal mucosal barrier function.

Semin Immunopathol. 2025-1-21

[4]
Polyamines: Key Players in Immunometabolism and Immune Regulation.

J Cell Immunol. 2024

[5]
Metabolism of Polyamines and Kidney Disease: A Promising Therapeutic Target.

Kidney Dis (Basel). 2023-8-10

[6]
Polyamines and hypusination are important for toxin B (TcdB)-mediated activation of group 3 innate lymphocytes (ILC3s).

Infect Immun. 2023-11-16

本文引用的文献

[1]
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.

Proc Natl Acad Sci U S A. 2022-11-8

[2]
Metabolic adaptation of lymphocytes in immunity and disease.

Immunity. 2022-1-11

[3]
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.

Gastroenterology. 2022-3

[4]
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.

Cell. 2021-8-5

[5]
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.

Cell. 2021-8-5

[6]
De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function.

Sci Adv. 2020-12

[7]
Polyamines and Kynurenines at the Intersection of Immune Modulation.

Trends Immunol. 2020-11

[8]
De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells.

Eur J Immunol. 2021-1

[9]
Functional interactions between innate lymphoid cells and adaptive immunity.

Nat Rev Immunol. 2019-7-26

[10]
ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands.

J Exp Med. 2019-7-11

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索