Lewis Natasha E, Sardana Rohan, Dogan Ahmet
Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Int J Hematol. 2023 Apr;117(4):475-491. doi: 10.1007/s12185-023-03537-7. Epub 2023 Jan 13.
Mature T-cell and NK-cell lymphomas are a heterogeneous group of rare and typically aggressive neoplasms. Diagnosis and subclassification have historically relied primarily on the integration of clinical, histologic, and immunophenotypic features, which often overlap. The widespread application of a variety of genomic techniques in recent years has provided extensive insight into the pathobiology of these diseases, allowing for more precise diagnostic classification, improved prognostication, and development of novel therapies. In this review, we summarize the genomic features of the most common types of mature T-cell and NK-cell lymphomas with a particular focus on the contribution of genomics to biologic insight, classification, risk stratification, and select therapies in the context of the recently published International Consensus and updated World Health Organization classification systems.
成熟T细胞和NK细胞淋巴瘤是一组异质性的罕见肿瘤，通常具有侵袭性。历史上，诊断和亚分类主要依靠整合临床、组织学和免疫表型特征，而这些特征常常相互重叠。近年来，各种基因组技术的广泛应用为这些疾病的病理生物学提供了深入见解，有助于更精确的诊断分类、改善预后以及开发新疗法。在本综述中，我们总结了最常见类型的成熟T细胞和NK细胞淋巴瘤的基因组特征，特别关注在最近发布的国际共识和更新的世界卫生组织分类系统背景下，基因组学对生物学认识、分类、风险分层及某些疗法的贡献。
